Soraprazan - a new regenerative therapy for Stargardt's disease

Project Information

Soraprazan

Grant agreement ID: 779317

DOI 10.3030/779317

Project closed

EC signature date 15 November 2017

Start date 1 December 2017

End date 30 November 2021

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 5 792 425,00

EU contribution € 5 792 425,00

Coordinated by

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany

Objective

Soraprazan – a new regenerative therapy for Stargardt’s disease
Abnormal accumulation of lipofuscin in the RPE cells is a hallmark in Stargardt's disease. As lipofuscin cannot be removed from the RPE cells in the eyes neither spontaneously nor with existing therapies, the accumulation of lipofuscin in the RPE cells of the eyes results in the degradation of the RPE cells and consequently in worsening of visual acuity and could lead to blindness. Soraprazan was able to show removal of lipofuscin in RPE cells. Aim of the phase II trial in this project is to evaluate savety and efficacy or orally taken Soraprazan treatment compared to placebo.

Fields of science

• medical and health sciences › clinical medicine › ophthalmology

Keywords

• lipofuscin
• vision loss
• depigmentation
• regenerative
• RPE cells
• Stargardt's disease

Programme(s)

• H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme
• H2020-EU.3.1.3. - Treating and managing disease

Topic(s)

• SC1-PM-11-2016-2017 - Clinical research on regenerative medicine

Call for proposal

H2020-SC1-2016-2017

See other projects for this call

Sub call

H2020-SC1-2017-Single-Stage-RTD

Funding Scheme

RIA - Research and Innovation action

Coordinator

EBERHARD KARLS UNIVERSITAET TUEBINGEN

• Net EU contribution: € 467 500,00
• Address: GESCHWISTER-SCHOLL-PLATZ ; 72074 Tuebingen ; Germany
• Region: Baden-Württemberg › Tübingen › Tübingen, Landkreis
• Activity type: Higher or Secondary Education Establishments
• Total cost: € 467 500,00

Participants (11)

KATAIRO GMBH

Germany

• Net EU contribution: € 2 705 000,00
• Address: LEDERSTR. 21 ; 72127 Kusterdingen
• SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes:
  Region
  Baden-Württemberg › Tübingen › Tübingen, Landkreis
• Region: Baden-Württemberg › Tübingen › Tübingen, Landkreis
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: € 2 705 000,00

STICHTING RADBOUD UNIVERSITEIT

Participation ended

Netherlands

• Net EU contribution: € 179 980,66
• Address: HOUTLAAN 4 ; 6525 XZ Nijmegen
• Region: Oost-Nederland › Gelderland › Arnhem/Nijmegen
• Activity type: Higher or Secondary Education Establishments
• Total cost: € 179 980,66

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

• Net EU contribution: € 178 222,50
• Address: ALBINUSDREEF 2 ; 2333 ZA Leiden
• Region: West-Nederland › Zuid-Holland › Agglomeratie Leiden en Bollenstreek
• Activity type: Higher or Secondary Education Establishments
• Total cost: € 178 222,50

UNIVERSITY OF SOUTHAMPTON

United Kingdom

• Net EU contribution: € 59 087,50
• Address: Highfield ; SO17 1BJ Southampton
• Region: South East (England) › Hampshire and Isle of Wight › Southampton
• Activity type: Higher or Secondary Education Establishments
• Total cost: € 252 500,00

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITY HOSPITALS SOUTHAMPTON NHS FOUNDATION TRUST

United Kingdom

• Net EU contribution: € 193 412,50
• Address: TREMONA ROAD ; SO16 6YD Southampton
• Region: South East (England) › Hampshire and Isle of Wight › Southampton
• Activity type: Research Organisations
• Total cost: € 193 412,50

OSPEDALE SAN RAFFAELE SRL

Italy

• Net EU contribution: € 180 171,25
• Address: VIA OLGETTINA 60 ; 20132 Milano
• Region: Nord-Ovest › Lombardia › Milano
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: € 180 171,25

SMERUD MEDICAL RESEARCH INTERNATIONAL AS

Norway

• Net EU contribution: € 561 250,00
• Address: KARENSLYST ALLE 6 ; 0278 Oslo
• SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes:
  Region
  Norge › Oslo og Viken › Oslo
• Region: Norge › Oslo og Viken › Oslo
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: € 1 561 250,00

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

SMERUD MEDICAL RESEARCH GERMANY GMBH

Germany

• Net EU contribution: € 883 750,00
• Address: O 7 1 ; 68161 Mannheim
• SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes:
  Region
  Baden-Württemberg › Karlsruhe › Mannheim, Stadtkreis
• Region: Baden-Württemberg › Karlsruhe › Mannheim, Stadtkreis
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: € 883 750,00

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

SMERUD MEDICAL RESEARCH UK LIMITED

United Kingdom

• Net EU contribution: € 116 250,00
• Address: SUITE 1S-B TRAFFORD HOUSE CHESTER ROAD TRETFORD ; M32 0RS Manchester
• SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes:
  Region
  North West (England) › Greater Manchester › Greater Manchester South West
• Region: North West (England) › Greater Manchester › Greater Manchester South West
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: € 116 250,00

UNIVERSITATSKLINIKUM BONN

Germany

• Net EU contribution: € 128 281,25
• Address: VENUSBERG-CAMPUS 1 ; 53127 Bonn
• Region: Nordrhein-Westfalen › Köln › Bonn, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Total cost: € 128 281,25

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM

Netherlands

• Net EU contribution: € 139 519,34
• Address: GEERT GROOTEPLEIN 10 ZUID ; 6525 GA Nijmegen
• Region: Oost-Nederland › Gelderland › Arnhem/Nijmegen
• Activity type: Higher or Secondary Education Establishments
• Total cost: € 139 519,34