Objective TWIST will build detector modules for PET scanners that offer high sensitivity together with precise position and time resolution. TWIST will deliver high-resolution PET images with low background using a lower dosage of radio-tracer. The breakthrough is obtained due to the successful development of the new Strip Silicon PhotoMultiplier (SSiPM) within the ERC TICAL project.PET (Positron Emission Tomography) scanners create images of the distribution of positron emitters in the body of subjects under investigation. PET scans have a fundamental advantage over other forms of medical imaging, such as CT scans; since they are sensitive to the functioning of biological processes. Biomarkers are involved in chemical reactions active inmolecular pathways of interest for diagnosing diseases; the image will alter according to molecular changes occurringwithin the area of interest. Since the imaging technique operates at the sub-cellular and molecular level of the body, it isknown as molecular imaging.Although PET imaging is a very powerful diagnostic tool, an injection of a radiotracer is required. The precise timeresolution of the TWIST modules with substantially reduce the background generating clearer images. The imageresolution will be further enhanced due to the determination of the 511 keV gamma interaction point (including the depth ofinteraction). Since the depth of interaction is well determined, longer crystals can be used and the detection modules canbe mounted close to the subject being scanned. This results in higher resolution images with a significant reduction (atleast x5) use of radio tracer.For all developments, it is important to move from tests in the laboratory to building a system of multiple units, because this is the stage that these new developments become useful and open up commercial possibilities. The creation of a business plan to manufacture modules on a commercial basis is integrated within this proposal. Fields of science engineering and technologymedical engineeringdiagnostic imagingcomputed tomographymedical and health sciencesclinical medicineradiologynuclear medicinenatural scienceschemical sciencesinorganic chemistrymetalloids Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-2017-PoC - ERC-Proof of Concept Call for proposal ERC-2017-PoC See other projects for this call Funding Scheme ERC-POC - Proof of Concept Grant Coordinator ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE Net EU contribution € 150 000,00 Address Esplanade des particules 1 parcelle 11482 de meyrin batiment cadastral 1046 1211 Geneve 23 Switzerland See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Beneficiaries (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE Switzerland Net EU contribution € 150 000,00 Address Esplanade des particules 1 parcelle 11482 de meyrin batiment cadastral 1046 1211 Geneve 23 See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
