Objective
Systemic inflammation contributes to the development of multiple organ dysfunction, the major cause of mortality in patients with septic shock. Systemic inflammation is a consequence of activation of the innate immune system. Recent studies have indicated that adipose tissue plays a major role in the secretion of inflammatory factors, which have been called adipo-cytokines or adipokines.
Also, the increased production rate of cytokines such as IL-6 or TNF-alpha has been implicated in the pathogenesis of car diovascular complications and insulin resistance. However, the metabolic role and possible consequences of adipose tissue as a secretory organ in critically ill patients has not been investigated to date. For the present proposal we will test the hypothesis, that adipose tissue is one of the links between systemic inflammation causing insulin resistance in critically ill patients and low-grade inflammation causing insulin resistance in obesity. To test this obesity we will characterize adipose tissue as a secretory organ using interstitial fluid sampling techniques and advanced peptide analysis in critically ill patients and healthy controls.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- social sciencessociologydemographymortality
- natural sciencesbiological sciencesbiochemistrybiomolecules
- medical and health sciencesbasic medicineimmunology
- medical and health scienceshealth sciencesnutritionobesity
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Call for proposal
FP6-2002-MOBILITY-7
See other projects for this call
Funding Scheme
IIF - Marie Curie actions-Incoming International FellowshipsCoordinator
GRAZ
Austria