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Nanoscale Biomeasurements of Nerve Cells and Vesicles: Molecular Substructure and the Nature of Exocytosis

Publications

Nanoscale Amperometry Reveals that Only a Fraction of Vesicular Serotonin Content is Released During Exocytosis from Beta Cells

Author(s): Amir Hatamie, Lin Ren, Haiqiang Dou, Nikhil R. Gandasi, Patrik Rorsman, Andrew Ewing
Published in: Angewandte Chemie International Edition, Issue 60/14, 2021, Page(s) 7593-7596, ISSN 1433-7851
DOI: 10.1002/anie.202015902

Nanoelectrochemical analysis inside a single living cell

Author(s): Xinwei Zhang, Amir Hatamie, Andrew G. Ewing
Published in: Current Opinion in Electrochemistry, Issue 22, 2020, Page(s) 94-101, ISSN 2451-9103
DOI: 10.1016/j.coelec.2020.05.008

Correlating Molecule Count and Release Kinetics with Vesicular Size Using Open Carbon Nanopipettes

Author(s): Keke Hu, Rui Jia, Amir Hatamie, Kim Long Le Vo, Michael V. Mirkin, Andrew G. Ewing
Published in: Journal of the American Chemical Society, Issue 142/40, 2020, Page(s) 16910-16914, ISSN 0002-7863
DOI: 10.1021/jacs.0c07169

Electrochemical Quantification of Neurotransmitters in Single Live Cell Vesicles Shows Exocytosis is Predominantly Partial

Author(s): Ying Wang, Andrew Ewing
Published in: ChemBioChem, Issue 22/5, 2021, Page(s) 807-813, ISSN 1439-4227
DOI: 10.1002/cbic.202000622

Chemical Analysis of Single Cells and Organelles

Author(s): Keke Hu, Tho D. K. Nguyen, Stefania Rabasco, Pieter E. Oomen, Andrew G. Ewing
Published in: Analytical Chemistry, Issue 93/1, 2021, Page(s) 41-71, ISSN 0003-2700
DOI: 10.1021/acs.analchem.0c04361

Mass Spectrometric Imaging of Plasma Membrane Lipid Alteration Correlated with Amperometrically Measured Activity-Dependent Plasticity in Exocytosis

Author(s): Chaoyi Gu, Mai H. Philipsen, Andrew G. Ewing
Published in: International Journal of Molecular Sciences, Issue 21/24, 2020, Page(s) 9519, ISSN 1422-0067
DOI: 10.3390/ijms21249519

Zinc Deficiency Leads to Lipid Changes in Drosophila Brain Similar to Cognitive‐Impairing Drugs: An Imaging Mass Spectrometry Study

Author(s): Mai H. Philipsen, Chaoyi Gu, Andrew G. Ewing
Published in: ChemBioChem, Issue 21/19, 2020, Page(s) 2755-2758, ISSN 1439-4227
DOI: 10.1002/cbic.202000197

Counteranions in the Stimulation Solution Alter the Dynamics of Exocytosis Consistent with the Hofmeister Series

Author(s): Xiulan He, Andrew G. Ewing
Published in: Journal of the American Chemical Society, Issue 142/29, 2020, Page(s) 12591-12595, ISSN 0002-7863
DOI: 10.1021/jacs.0c05319

Intracellular injection of phospholipids directly alters exocytosis and the fraction of chemical release in chromaffin cells as measured by nano-electrochemistry

Author(s): Mohaddeseh Aref, Elias Ranjbari, Armaghan Romiani, Andrew G. Ewing
Published in: Chemical Science, Issue 11/43, 2020, Page(s) 11869-11876, ISSN 2041-6520
DOI: 10.1039/d0sc03683h

Subcellular Mass Spectrometry Imaging and Absolute Quantitative Analysis across Organelles

Author(s): Aurélien Thomen, Neda Najafinobar, Florent Penen, Emma Kay, Pratik P. Upadhyay, Xianchan Li, Nhu T. N. Phan, Per Malmberg, Magnus Klarqvist, Shalini Andersson, Michael E. Kurczy, Andrew G. Ewing
Published in: ACS Nano, Issue 14/4, 2020, Page(s) 4316-4325, ISSN 1936-0851
DOI: 10.1021/acsnano.9b09804

Anticancer Drug Tamoxifen Affects Catecholamine Transmitter Release and Storage from Single Cells

Author(s): Zahra Taleat, Anna Larsson, Andrew G. Ewing
Published in: ACS Chemical Neuroscience, Issue 10/4, 2019, Page(s) 2060-2069, ISSN 1948-7193
DOI: 10.1021/acschemneuro.8b00714

Dopamine Release Dynamics in the Tuberoinfundibular Dopamine System

Author(s): Stefanos Stagkourakis, Johan Dunevall, Zahra Taleat, Andrew G. Ewing, Christian Broberger
Published in: The Journal of Neuroscience, Issue 39/21, 2019, Page(s) 4009-4022, ISSN 0270-6474
DOI: 10.1523/jneurosci.2339-18.2019

Extracellular ATP Regulates the Vesicular Pore Opening in Chromaffin Cells and Increases the Fraction Released During Individual Exocytosis Events

Author(s): Soodabeh Majdi, Anna Larsson, Neda Najafinobar, Ricardo Borges, Andrew G. Ewing
Published in: ACS Chemical Neuroscience, Issue 10/5, 2019, Page(s) 2459-2466, ISSN 1948-7193
DOI: 10.1021/acschemneuro.8b00722

Combined Amperometry and Electrochemical Cytometry Reveal Differential Effects of Cocaine and Methylphenidate on Exocytosis and the Fraction of Chemical Release

Author(s): Wanying Zhu, Chaoyi Gu, Johan Dunevall, Lin Ren, Xuemin Zhou, Andrew G. Ewing
Published in: Angewandte Chemie, Issue 131/13, 2019, Page(s) 4282-4286, ISSN 0044-8249
DOI: 10.1002/ange.201813717

Interplay between Cocaine, Drug Removal, and Methylphenidate Reversal on Phospholipid Alterations in Drosophila Brain Determined by Imaging Mass Spectrometry

Author(s): Mai Hoang Philipsen, Nhu T. N. Phan, John Stephen Fletcher, Andrew G. Ewing
Published in: ACS Chemical Neuroscience, Issue 11/5, 2020, Page(s) 806-813, ISSN 1948-7193
DOI: 10.1021/acschemneuro.0c00014

Spatial Lipidomics Reveals Region and Long Chain Base Specific Accumulations of Monosialogangliosides in Amyloid Plaques in Familial Alzheimer’s Disease Mice (5xFAD) Brain

Author(s): Ibrahim Kaya, Eva Jennische, Johan Dunevall, Stefan Lange, Andrew G. Ewing, Per Malmberg, Ahmet Tarik Baykal, John S. Fletcher
Published in: ACS Chemical Neuroscience, Issue 11/1, 2020, Page(s) 14-24, ISSN 1948-7193
DOI: 10.1021/acschemneuro.9b00532

Mass spectrometry imaging as a novel approach to measure hippocampal zinc

Author(s): Masoumeh Dowlatshahi Pour, Lin Ren, Eva Jennische, Stefan Lange, Andrew G. Ewing, Per Malmberg
Published in: Journal of Analytical Atomic Spectrometry, Issue 34/8, 2019, Page(s) 1581-1587, ISSN 0267-9477
DOI: 10.1039/c9ja00199a

Vesicular Transmitter Content in Chromaffin Cells Can Be Regulated via Extracellular ATP

Author(s): Anna Larsson, Soodabeh Majdi, Ricardo Borges, Andrew Ewing
Published in: ACS Chemical Neuroscience, Issue 10/11, 2019, Page(s) 4735-4740, ISSN 1948-7193
DOI: 10.1021/acschemneuro.9b00494

Altered Lipid Composition of Secretory Cells Following Exposure to Zinc Can Be Correlated to Changes in Exocytosis

Author(s): Lin Ren, Masoumeh Dowlatshahi Pour, Per Malmberg, Andrew G. Ewing
Published in: Chemistry – A European Journal, Issue 25/21, 2019, Page(s) 5406-5411, ISSN 0947-6539
DOI: 10.1002/chem.201900010

Intracellular Electrochemical Nanomeasurements Reveal that Exocytosis of Molecules at Living Neurons is Subquantal and Complex

Author(s): Anna Larsson, Soodabeh Majdi, Alexander Oleinick, Irina Svir, Johan Dunevall, Christian Amatore, Andrew G. Ewing
Published in: Angewandte Chemie International Edition, 2020, ISSN 1433-7851
DOI: 10.1002/anie.201914564

Plasticity in exocytosis revealed through the effects of repetitive stimuli affect the content of nanometer vesicles and the fraction of transmitter released

Author(s): Chaoyi Gu, Anna Larsson, Andrew G. Ewing
Published in: Proceedings of the National Academy of Sciences, Issue 116/43, 2019, Page(s) 21409-21415, ISSN 0027-8424
DOI: 10.1073/pnas.1910859116

Using Single-Cell Amperometry and Intracellular Vesicle Impact Electrochemical Cytometry To Shed Light on the Biphasic Effects of Lidocaine on Exocytosis

Author(s): Daixin Ye, Chaoyi Gu, Andrew Ewing
Published in: ACS Chemical Neuroscience, Issue 9/12, 2018, Page(s) 2941-2947, ISSN 1948-7193
DOI: 10.1021/acschemneuro.8b00130

Amperometric Measurements and Dynamic Models Reveal a Mechanism for How Zinc Alters Neurotransmitter Release

Author(s): Lin Ren, Alexander Oleinick, Irina Svir, Christian Amatore, Andrew G. Ewing
Published in: Angewandte Chemie International Edition, Issue 59/8, 2020, Page(s) 3083-3087, ISSN 1433-7851
DOI: 10.1002/anie.201913184

On-Tissue Chemical Derivatization of Catecholamines Using 4-( N -Methyl)pyridinium Boronic Acid for ToF-SIMS and LDI-ToF Mass Spectrometry Imaging

Author(s): Ibrahim Kaya, Steffen M. Brülls, Johan Dunevall, Eva Jennische, Stefan Lange, Jerker Mårtensson, Andrew G. Ewing, Per Malmberg, John S. Fletcher
Published in: Analytical Chemistry, Issue 90/22, 2018, Page(s) 13580-13590, ISSN 0003-2700
DOI: 10.1021/acs.analchem.8b03746

Simultaneous Quantification of Vesicle Size and Catecholamine Content by Resistive Pulses in Nanopores and Vesicle Impact Electrochemical Cytometry

Author(s): Xin-Wei Zhang, Amir Hatamie, Andrew G. Ewing
Published in: Journal of the American Chemical Society, Issue 142/9, 2020, Page(s) 4093-4097, ISSN 0002-7863
DOI: 10.1021/jacs.9b13221

Comparison of Disk and Nanotip Electrodes for Measurement of Single-Cell Amperometry during Exocytotic Release

Author(s): Chaoyi Gu, Xinwei Zhang, Andrew G. Ewing
Published in: Analytical Chemistry, Issue 92/15, 2020, Page(s) 10268-10273, ISSN 0003-2700
DOI: 10.1021/acs.analchem.0c02013

Direct Measurement of Total Vesicular Catecholamine Content with Electrochemical Microwell Arrays

Author(s): Elias Ranjbari, Zahra Taleat, Mokhtar Mapar, Mohaddeseh Aref, Johan Dunevall, Andrew Ewing
Published in: Analytical Chemistry, Issue 92/16, 2020, Page(s) 11325-11331, ISSN 0003-2700
DOI: 10.1021/acs.analchem.0c02010