Harnessing the Molecules of Medicinal Plants

Project Information

MedPlant

Grant agreement ID: 788301

DOI

10.3030/788301

Project closed

EC signature date 5 June 2018

Start date 1 July 2018

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 999,00

EU contribution

€ 2 499 999,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (21)

Recycling upstream redox enzymes expands the regioselectivity of cycloaddition in pseudo-aspidosperma alkaloid biosynthesis

Author(s): Mohamed O. Kamileen; Matthew D. DeMars; Benke Hong; Yoko Nakamura; Christian Paetz; Benjamin R. Lichman; Prashant D. Sonawane; Lorenzo Caputi; Sarah E. O’Connor
Published in: Journal of the American Chemical Society, Issue 1, 2022, Page(s) 19673 - 19579, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1101/2022.09.13.507834

Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids

Author(s): Lorenzo Caputi, Jakob Franke, Kate Bussey, Scott C. Farrow, Ivo Jose Curcino Vieira, Clare E. M. Stevenson, David M. Lawson, Sarah E. O’Connor
Published in: Nature Chemical Biology, Issue 16/4, 2020, Page(s) 383-386, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-019-0460-x

Early and Late Steps of Quinine Biosynthesis.

Author(s): Francesco Trenti; Kotaro Yamamoto; Benke Hong; Christian Paetz; Yoko Nakamura; Sarah E. O'Connor
Published in: Organic Letters, Issue 1, 2021, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.1c00206

Biosynthesis of strychnine

Author(s): Benke Hong; Dagny Grzech; Lorenzo Caputi; Prashant Sonawane; Carlos E. Rodríguez López; Mohamed Omar Kamileen; Néstor J. Hernández Lozada; Veit Grabe; Sarah E. O’Connor
Published in: Nature, Issue 1, 2022, Page(s) 617 - 622, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04950-4

In vivo characterization of key iridoid biosynthesis pathway genes in catnip (Nepeta cataria)

Author(s): Lira Palmer; Ling Chuang; Marlen Siegmund; Maritta Kunert; Kotaro Yamamoto; Prashant Sonawane; Sarah E. O’Connor
Published in: Planta, Issue 1, 2022, ISSN 0032-0935
Publisher: Springer Verlag
DOI: 10.1007/s00425-022-04012-z

Directed Biosynthesis of New to Nature Alkaloids in a Heterologous Nicotiana benthamiana Expression Host

Author(s): Marianna Boccia; Dagny Grzech; Adriana A. Lopes; Sarah E. O’Connor; Lorenzo Caputi
Published in: Frontiers in Plant Science, Issue 5, 2022, ISSN 1664-462X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fpls.2022.919443

Engineering the Biosynthesis of Late-Stage Vinblastine Precursors Precondylocarpine Acetate, Catharanthine, Tabersonine in <i>Nicotiana benthamiana</i>

Author(s): Dagny Grzech; Benke Hong; Lorenzo Caputi; Prashant D. Sonawane; Sarah E. O’Connor
Published in: ACS Synthetic Biology, Issue 1, 2023, Page(s) 27 - 34, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.2c00434

Identifying Missing Biosynthesis Enzymes of Plant Natural Products

Author(s): Thomas Dugé de Bernonville, Nicolas Papon, Marc Clastre, Sarah E. O’Connor, Vincent Courdavault
Published in: Trends in Pharmacological Sciences, Issue 41/3, 2020, Page(s) 142-146, ISSN 0165-6147
Publisher: Elsevier BV
DOI: 10.1016/j.tips.2019.12.006

Reinventing metabolic pathways: Independent evolution of benzoxazinoids in flowering plants

Author(s): Matilde Florean; Katrin Luck; Benke Hong; Yoko Nakamura; Sarah E. O’Connor; Tobias G. Köllner
Published in: Proceedings of the National Academy of Sciences of the United States of America, Issue 5, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2307981120

Towards the Microbial Production of Plant-Derived Anticancer Drugs

Author(s): Vincent Courdavault, Sarah E. O’Connor, Audrey Oudin, Sébastien Besseau, Nicolas Papon
Published in: Trends in Cancer, Issue 6/6, 2020, Page(s) 444-448, ISSN 2405-8033
Publisher: Elsevier BV
DOI: 10.1016/j.trecan.2020.02.004

Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs

Author(s): Ines Carqueijeiro, Chloe Langley, Dagny Grzech, Konstantinos Koudounas, Nicolas Papon, Sarah E O’Connor, Vincent Courdavault
Published in: Current Opinion in Biotechnology, Issue 65, 2020, Page(s) 17-24, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2019.11.017

Biosynthesis of iridoid sex pheromones in aphids

Author(s): Tobias G. Köllner; Anja David; Katrin Luck; Franziska Beran; Grit Kunert; Jing-Jiang Zhou; Lorenzo Caputi; Sarah E. O’Connor
Published in: Proceedings of the National Academy of Sciences of the United States of America, Issue 1, 2022, Page(s) e2211254119, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1101/2022.09.13.507830

Improved virus-induced gene silencing allows discovery of a serpentine synthase gene in Catharanthus roseus.

Author(s): Kotaro Yamamoto; Kotaro Yamamoto; Dagny Grzech; Konstantinos Koudounas; Emily Amor Stander; Lorenzo Caputi; Tetsuro Mimura; Vincent Courdavault; Sarah E. O'Connor
Published in: Plant Physiology, Issue 1, 2021, ISSN 0032-0889
Publisher: American Society of Plant Biologists
DOI: 10.1093/plphys/kiab285

Single-cell multi-omics in the medicinal plant Catharanthus roseus

Author(s): Chenxin Li; Joshua C. Wood; Anh Hai Vu; John P. Hamilton; Carlos Eduardo Rodriguez Lopez; Richard M. E. Payne; Delia Ayled Serna Guerrero; Klaus Gase; Kotaro Yamamoto; Brieanne Vaillancourt; Lorenzo Caputi; Sarah E. O’Connor; C. Robin Buell
Published in: Nature Chemical Biology, Issue 2, 2023, Page(s) 1031 - 1041, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-023-01327-0

Nicotiana benthamiana as a Transient Expression Host to Produce Auxin Analogs

Author(s): Katharine Davis, Danai S. Gkotsi, Duncan R. M. Smith, Rebecca J. M. Goss, Lorenzo Caputi, Sarah E. O’Connor
Published in: Frontiers in Plant Science, Issue 11, 2020, ISSN 1664-462X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fpls.2020.581675

Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism

Author(s): Chloe Langley; Evangelos Tatsis; Benke Hong; Yoko Nakamura; Christian Paetz; Clare E. M. Stevenson; Jerome Basquin; David M. Lawson; Lorenzo Caputi; Sarah E. O'Connor
Published in: Angewandte Chemie, International Edition in English, Issue 1, 2022, ISSN 0570-0833
Publisher: Wiley-VCH
DOI: 10.1101/2022.07.24.501124

Promiscuous CYP87A enzyme activity initiates cardenolide biosynthesis in plants

Author(s): Maritta Kunert; Chloe Langley; Rosalind Lucier; Kerstin Ploss; Carlos E. Rodríguez López; Delia A. Serna Guerrero; Eva Rothe; Sarah E. O’Connor; Prashant D. Sonawane
Published in: Nature Plants, Issue 1, 2023, Page(s) 1607 - 1617, ISSN 2055-0278
Publisher: Nature Publishing Group
DOI: 10.1038/s41477-023-01515-9

Directed Biosynthesis of Mitragynine Stereoisomers

Author(s): Carsten Schotte; Yindi Jiang; Dagny Grzech; Thu-Thuy T. Dang; Larissa C. Laforest; Francisco León; Marco Mottinelli; Satya Swathi Nadakuduti; Christopher R. McCurdy; Sarah E. O’Connor
Published in: Journal of the American Chemical Society, Issue 1, 2023, Page(s) 4957 - 4963, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1101/2022.12.22.521574

Biocatalytic routes to stereo-divergent iridoids

Author(s): Néstor J. Hernández Lozada; Benke Hong; Joshua C. Wood; Lorenzo Caputi; Jérôme Basquin; Ling Chuang; Maritta Kunert; Carlos E. Rodríguez López; Chloe Langley; Dongyan Zhao; C. Robin Buell; Benjamin R. Lichman; Sarah E. O’Connor
Published in: Nature Communications, Issue 1, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32414-w

The Mitragyna speciosa (Kratom) Genome: a resource for data-mining potent pharmaceuticals that impact human health

Author(s): Julia Brose; Kin H. Lau; Thu Thuy Thi Dang; John P. Hamilton; Lívia do Vale Martins; Lívia do Vale Martins; Britta Hamberger; Bjoern Hamberger; Jiming Jiang; Sarah E. O'Connor; C. Robin Buell
Published in: G3: Genes, Genomes, Genetics, Issue 1, 2021, ISSN 2160-1836
Publisher: Genetics Society of America
DOI: 10.1093/g3journal/jkab058

Biosynthesis of an Anti-Addiction Agent from the Iboga Plant

Author(s): Scott C. Farrow, Mohamed O. Kamileen, Lorenzo Caputi, Kate Bussey, Julia E. A. Mundy, Rory C. McAtee, Corey R. J. Stephenson, Sarah E. O’Connor
Published in: Journal of the American Chemical Society, Issue 141/33, 2019, Page(s) 12979-12983, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b05999

Other (1)

Evolution and Diversification of Carboxylesterase-like [4+2] Cyclases in Aspidosperma and Iboga Alkaloid Biosynthesis

Author(s): Matthew D. DeMars; Sarah E. O’Connor
Published in: bioRxiv : the preprint server for biology, Issue 4, 2023, ISSN 2692-8205
Publisher: bioRxiv.org
DOI: 10.1101/2023.10.24.563752