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Harnessing the Molecules of Medicinal Plants

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Publications

Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids

Author(s): Lorenzo Caputi, Jakob Franke, Kate Bussey, Scott C. Farrow, Ivo Jose Curcino Vieira, Clare E. M. Stevenson, David M. Lawson, Sarah E. O’Connor
Published in: Nature Chemical Biology, 16/4, 2020, Page(s) 383-386, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-019-0460-x

Early and Late Steps of Quinine Biosynthesis.

Author(s): Francesco Trenti; Kotaro Yamamoto; Benke Hong; Christian Paetz; Yoko Nakamura; Sarah E. O'Connor
Published in: Organic Letters, 1, 2021, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.1c00206

Identifying Missing Biosynthesis Enzymes of Plant Natural Products

Author(s): Thomas Dugé de Bernonville, Nicolas Papon, Marc Clastre, Sarah E. O’Connor, Vincent Courdavault
Published in: Trends in Pharmacological Sciences, 41/3, 2020, Page(s) 142-146, ISSN 0165-6147
Publisher: Elsevier BV
DOI: 10.1016/j.tips.2019.12.006

Towards the Microbial Production of Plant-Derived Anticancer Drugs

Author(s): Vincent Courdavault, Sarah E. O’Connor, Audrey Oudin, Sébastien Besseau, Nicolas Papon
Published in: Trends in Cancer, 6/6, 2020, Page(s) 444-448, ISSN 2405-8033
Publisher: Elsevier BV
DOI: 10.1016/j.trecan.2020.02.004

Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs

Author(s): Ines Carqueijeiro, Chloe Langley, Dagny Grzech, Konstantinos Koudounas, Nicolas Papon, Sarah E O’Connor, Vincent Courdavault
Published in: Current Opinion in Biotechnology, 65, 2020, Page(s) 17-24, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2019.11.017

Improved virus-induced gene silencing allows discovery of a serpentine synthase gene in Catharanthus roseus.

Author(s): Kotaro Yamamoto; Kotaro Yamamoto; Dagny Grzech; Konstantinos Koudounas; Emily Amor Stander; Lorenzo Caputi; Tetsuro Mimura; Vincent Courdavault; Sarah E. O'Connor
Published in: Plant Physiology, 1, 2021, ISSN 0032-0889
Publisher: American Society of Plant Biologists
DOI: 10.1093/plphys/kiab285

Nicotiana benthamiana as a Transient Expression Host to Produce Auxin Analogs

Author(s): Katharine Davis, Danai S. Gkotsi, Duncan R. M. Smith, Rebecca J. M. Goss, Lorenzo Caputi, Sarah E. O’Connor
Published in: Frontiers in Plant Science, 11, 2020, ISSN 1664-462X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fpls.2020.581675

The Mitragyna speciosa (Kratom) Genome: a resource for data-mining potent pharmaceuticals that impact human health

Author(s): Julia Brose; Kin H. Lau; Thu Thuy Thi Dang; John P. Hamilton; Lívia do Vale Martins; Lívia do Vale Martins; Britta Hamberger; Bjoern Hamberger; Jiming Jiang; Sarah E. O'Connor; C. Robin Buell
Published in: G3: Genes, Genomes, Genetics, 1, 2021, ISSN 2160-1836
Publisher: Genetics Society of America
DOI: 10.1093/g3journal/jkab058

Biosynthesis of an Anti-Addiction Agent from the Iboga Plant

Author(s): Scott C. Farrow, Mohamed O. Kamileen, Lorenzo Caputi, Kate Bussey, Julia E. A. Mundy, Rory C. McAtee, Corey R. J. Stephenson, Sarah E. O’Connor
Published in: Journal of the American Chemical Society, 141/33, 2019, Page(s) 12979-12983, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b05999