Harnessing the Molecules of Medicinal Plants

Project Information

MedPlant

Grant agreement ID: 788301

DOI 10.3030/788301

Project closed

EC signature date 5 June 2018

Start date 1 July 2018

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 499 999,00

EU contribution € 2 499 999,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

Publications

Peer reviewed articles (21)

Recycling upstream redox enzymes expands the regioselectivity of cycloaddition in pseudo-aspidosperma alkaloid biosynthesis

Author(s): Mohamed O. Kamileen; Matthew D. DeMars; Benke Hong; Yoko Nakamura; Christian Paetz; Benjamin R. Lichman; Prashant D. Sonawane; Lorenzo Caputi; Sarah E. O’Connor
Published in: Journal of the American Chemical Society, Issue 1, 2022, Page(s) 19673 - 19579, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1101/2022.09.13.507834

Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids

Author(s): Lorenzo Caputi, Jakob Franke, Kate Bussey, Scott C. Farrow, Ivo Jose Curcino Vieira, Clare E. M. Stevenson, David M. Lawson, Sarah E. O’Connor
Published in: Nature Chemical Biology, Issue 16/4, 2020, Page(s) 383-386, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-019-0460-x

Early and Late Steps of Quinine Biosynthesis.

Author(s): Francesco Trenti; Kotaro Yamamoto; Benke Hong; Christian Paetz; Yoko Nakamura; Sarah E. O'Connor
Published in: Organic Letters, Issue 1, 2021, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.1c00206

Biosynthesis of strychnine

Author(s): Benke Hong; Dagny Grzech; Lorenzo Caputi; Prashant Sonawane; Carlos E. Rodríguez López; Mohamed Omar Kamileen; Néstor J. Hernández Lozada; Veit Grabe; Sarah E. O’Connor
Published in: Nature, Issue 1, 2022, Page(s) 617 - 622, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04950-4

In vivo characterization of key iridoid biosynthesis pathway genes in catnip (Nepeta cataria)

Author(s): Lira Palmer; Ling Chuang; Marlen Siegmund; Maritta Kunert; Kotaro Yamamoto; Prashant Sonawane; Sarah E. O’Connor
Published in: Planta, Issue 1, 2022, ISSN 0032-0935
Publisher: Springer Verlag
DOI: 10.1007/s00425-022-04012-z

Directed Biosynthesis of New to Nature Alkaloids in a Heterologous Nicotiana benthamiana Expression Host

Author(s): Marianna Boccia; Dagny Grzech; Adriana A. Lopes; Sarah E. O’Connor; Lorenzo Caputi
Published in: Frontiers in Plant Science, Issue 5, 2022, ISSN 1664-462X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fpls.2022.919443

Engineering the Biosynthesis of Late-Stage Vinblastine Precursors Precondylocarpine Acetate, Catharanthine, Tabersonine in <i>Nicotiana benthamiana</i>

Author(s): Dagny Grzech; Benke Hong; Lorenzo Caputi; Prashant D. Sonawane; Sarah E. O’Connor
Published in: ACS Synthetic Biology, Issue 1, 2023, Page(s) 27 - 34, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.2c00434

Identifying Missing Biosynthesis Enzymes of Plant Natural Products

Author(s): Thomas Dugé de Bernonville, Nicolas Papon, Marc Clastre, Sarah E. O’Connor, Vincent Courdavault
Published in: Trends in Pharmacological Sciences, Issue 41/3, 2020, Page(s) 142-146, ISSN 0165-6147
Publisher: Elsevier BV
DOI: 10.1016/j.tips.2019.12.006

Reinventing metabolic pathways: Independent evolution of benzoxazinoids in flowering plants

Author(s): Matilde Florean; Katrin Luck; Benke Hong; Yoko Nakamura; Sarah E. O’Connor; Tobias G. Köllner
Published in: Proceedings of the National Academy of Sciences of the United States of America, Issue 5, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2307981120

Towards the Microbial Production of Plant-Derived Anticancer Drugs

Author(s): Vincent Courdavault, Sarah E. O’Connor, Audrey Oudin, Sébastien Besseau, Nicolas Papon
Published in: Trends in Cancer, Issue 6/6, 2020, Page(s) 444-448, ISSN 2405-8033
Publisher: Elsevier BV
DOI: 10.1016/j.trecan.2020.02.004

Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs

Author(s): Ines Carqueijeiro, Chloe Langley, Dagny Grzech, Konstantinos Koudounas, Nicolas Papon, Sarah E O’Connor, Vincent Courdavault
Published in: Current Opinion in Biotechnology, Issue 65, 2020, Page(s) 17-24, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2019.11.017

Biosynthesis of iridoid sex pheromones in aphids

Author(s): Tobias G. Köllner; Anja David; Katrin Luck; Franziska Beran; Grit Kunert; Jing-Jiang Zhou; Lorenzo Caputi; Sarah E. O’Connor
Published in: Proceedings of the National Academy of Sciences of the United States of America, Issue 1, 2022, Page(s) e2211254119, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1101/2022.09.13.507830

Improved virus-induced gene silencing allows discovery of a serpentine synthase gene in Catharanthus roseus.

Author(s): Kotaro Yamamoto; Kotaro Yamamoto; Dagny Grzech; Konstantinos Koudounas; Emily Amor Stander; Lorenzo Caputi; Tetsuro Mimura; Vincent Courdavault; Sarah E. O'Connor
Published in: Plant Physiology, Issue 1, 2021, ISSN 0032-0889
Publisher: American Society of Plant Biologists
DOI: 10.1093/plphys/kiab285

Single-cell multi-omics in the medicinal plant Catharanthus roseus

Author(s): Chenxin Li; Joshua C. Wood; Anh Hai Vu; John P. Hamilton; Carlos Eduardo Rodriguez Lopez; Richard M. E. Payne; Delia Ayled Serna Guerrero; Klaus Gase; Kotaro Yamamoto; Brieanne Vaillancourt; Lorenzo Caputi; Sarah E. O’Connor; C. Robin Buell
Published in: Nature Chemical Biology, Issue 2, 2023, Page(s) 1031 - 1041, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-023-01327-0

Nicotiana benthamiana as a Transient Expression Host to Produce Auxin Analogs

Author(s): Katharine Davis, Danai S. Gkotsi, Duncan R. M. Smith, Rebecca J. M. Goss, Lorenzo Caputi, Sarah E. O’Connor
Published in: Frontiers in Plant Science, Issue 11, 2020, ISSN 1664-462X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fpls.2020.581675

Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism

Author(s): Chloe Langley; Evangelos Tatsis; Benke Hong; Yoko Nakamura; Christian Paetz; Clare E. M. Stevenson; Jerome Basquin; David M. Lawson; Lorenzo Caputi; Sarah E. O'Connor
Published in: Angewandte Chemie, International Edition in English, Issue 1, 2022, ISSN 0570-0833
Publisher: Wiley-VCH
DOI: 10.1101/2022.07.24.501124

Promiscuous CYP87A enzyme activity initiates cardenolide biosynthesis in plants

Author(s): Maritta Kunert; Chloe Langley; Rosalind Lucier; Kerstin Ploss; Carlos E. Rodríguez López; Delia A. Serna Guerrero; Eva Rothe; Sarah E. O’Connor; Prashant D. Sonawane
Published in: Nature Plants, Issue 1, 2023, Page(s) 1607 - 1617, ISSN 2055-0278
Publisher: Nature Publishing Group
DOI: 10.1038/s41477-023-01515-9

Directed Biosynthesis of Mitragynine Stereoisomers

Author(s): Carsten Schotte; Yindi Jiang; Dagny Grzech; Thu-Thuy T. Dang; Larissa C. Laforest; Francisco León; Marco Mottinelli; Satya Swathi Nadakuduti; Christopher R. McCurdy; Sarah E. O’Connor
Published in: Journal of the American Chemical Society, Issue 1, 2023, Page(s) 4957 - 4963, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1101/2022.12.22.521574

Biocatalytic routes to stereo-divergent iridoids

Author(s): Néstor J. Hernández Lozada; Benke Hong; Joshua C. Wood; Lorenzo Caputi; Jérôme Basquin; Ling Chuang; Maritta Kunert; Carlos E. Rodríguez López; Chloe Langley; Dongyan Zhao; C. Robin Buell; Benjamin R. Lichman; Sarah E. O’Connor
Published in: Nature Communications, Issue 1, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32414-w

The Mitragyna speciosa (Kratom) Genome: a resource for data-mining potent pharmaceuticals that impact human health

Author(s): Julia Brose; Kin H. Lau; Thu Thuy Thi Dang; John P. Hamilton; Lívia do Vale Martins; Lívia do Vale Martins; Britta Hamberger; Bjoern Hamberger; Jiming Jiang; Sarah E. O'Connor; C. Robin Buell
Published in: G3: Genes, Genomes, Genetics, Issue 1, 2021, ISSN 2160-1836
Publisher: Genetics Society of America
DOI: 10.1093/g3journal/jkab058

Biosynthesis of an Anti-Addiction Agent from the Iboga Plant

Author(s): Scott C. Farrow, Mohamed O. Kamileen, Lorenzo Caputi, Kate Bussey, Julia E. A. Mundy, Rory C. McAtee, Corey R. J. Stephenson, Sarah E. O’Connor
Published in: Journal of the American Chemical Society, Issue 141/33, 2019, Page(s) 12979-12983, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b05999

Other (1)

Evolution and Diversification of Carboxylesterase-like [4+2] Cyclases in Aspidosperma and Iboga Alkaloid Biosynthesis

Author(s): Matthew D. DeMars; Sarah E. O’Connor
Published in: bioRxiv : the preprint server for biology, Issue 4, 2023, ISSN 2692-8205
Publisher: bioRxiv.org
DOI: 10.1101/2023.10.24.563752