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Regeneration of Articular Cartilage using Advanced Biomaterials and Printing Technology

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Bone biomaterials for overcoming antimicrobial resistance: Advances in non-antibiotic antimicrobial approaches for regeneration of infected osseous tissue

Author(s): Joanna M. Sadowska, Katelyn J. Genoud, Daniel J. Kelly, Fergal J. O'Brien
Published in: Materials Today, 2021, ISSN 1369-7021
DOI: 10.1016/j.mattod.2020.12.018

The development of natural polymer scaffold-based therapeutics for osteochondral repair

Author(s): Mark Lemoine, Sarah M. Casey, John M. O'Byrne, Daniel J. Kelly, Fergal J. O'Brien
Published in: Biochemical Society Transactions, Issue 48/4, 2020, Page(s) 1433-1445, ISSN 0300-5127
DOI: 10.1042/bst20190938

Layered Double Hydroxide as a Potent Non-viral Vector for Nucleic Acid Delivery Using Gene-Activated Scaffolds for Tissue Regeneration Applications

Author(s): Lara S. Costard, Domhnall C. Kelly, Rachael N. Power, Christopher Hobbs, Sonia Jaskaniec, Valeria Nicolosi, Brenton L. Cavanagh, Caroline M. Curtin, Fergal J. O’Brien
Published in: Pharmaceutics, Issue 12/12, 2020, Page(s) 1219, ISSN 1999-4923
DOI: 10.3390/pharmaceutics12121219

Rapid bone repair with the recruitment of CD206+M2-like macrophages using non-viral scaffold-mediated miR-133a inhibition of host cells

Author(s): Irene Mencía Castaño, Rosanne M. Raftery, Gang Chen, Brenton Cavanagh, Brian Quinn, Garry P. Duffy, Fergal J. O'Brien, Caroline M. Curtin
Published in: Acta Biomaterialia, Issue 109, 2020, Page(s) 267-279, ISSN 1742-7061
DOI: 10.1016/j.actbio.2020.03.042

Non-viral Gene Delivery of Interleukin-1 Receptor Antagonist Using Collagen-Hydroxyapatite Scaffold Protects Rat BM-MSCs From IL-1β-Mediated Inhibition of Osteogenesis

Author(s): William A. Lackington, Maria Antonia Gomez-Sierra, Arlyng González-Vázquez, Fergal J. O’Brien, Martin J. Stoddart, Keith Thompson
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
DOI: 10.3389/fbioe.2020.582012

Activation of the SOX‐5, SOX‐6, and SOX‐9 Trio of Transcription Factors Using a Gene‐Activated Scaffold Stimulates Mesenchymal Stromal Cell Chondrogenesis and Inhibits Endochondral Ossification

Author(s): Rosanne M. Raftery, Arlyng G. Gonzalez Vazquez, Gang Chen, Fergal J. O'Brien
Published in: Advanced Healthcare Materials, Issue 9/10, 2020, Page(s) 1901827, ISSN 2192-2640
DOI: 10.1002/adhm.201901827

Accelerating bone healing in vivo by harnessing the age-altered activation of c-Jun N-terminal kinase 3

Author(s): Arlyng González-Vázquez, Rosanne M. Raftery, Suzan Günbay, Gang Chen, Dylan J. Murray, Fergal J. O'Brien
Published in: Biomaterials, Issue 268, 2021, Page(s) 120540, ISSN 0142-9612
DOI: 10.1016/j.biomaterials.2020.120540

The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

Author(s): Tom Hodgkinson, P. Monica Tsimbouri, Virginia Llopis-Hernandez, Paul Campsie, David Scurr, Peter G. Childs, David Phillips, Sam Donnelly, Julia A. Wells, Fergal J. O’Brien, Manuel Salmeron-Sanchez, Karl Burgess, Morgan Alexander, Massimo Vassalli, Richard O. C. Oreffo, Stuart Reid, David J. France, Matthew J. Dalby
Published in: Science Advances, Issue 7/9, 2021, Page(s) eabb7921, ISSN 2375-2548
DOI: 10.1126/sciadv.abb7921