Publications Peer reviewed articles (22) Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications Author(s): Power, R.N.; Cavanagh, B.L.; Dixon, J.E.; Curtin, C.M.; O'Brien, F.J. Published in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms23031460 The Impact of the Extracellular Matrix Environment on Sost Expression by the MLO-Y4 Osteocyte Cell Line Author(s): Brady, R.T.; O'Brien, F.J.; Hoey, D.A. Published in: Bioengineering, 2022, ISSN 2306-5354 Publisher: MDPI DOI: 10.3390/bioengineering9010035 Bone biomaterials for overcoming antimicrobial resistance: Advances in non-antibiotic antimicrobial approaches for regeneration of infected osseous tissue Author(s): Joanna M. Sadowska, Katelyn J. Genoud, Daniel J. Kelly, Fergal J. O'Brien Published in: Materials Today, 2021, ISSN 1369-7021 Publisher: Elsevier BV DOI: 10.1016/j.mattod.2020.12.018 Translational Studies on the Potential of a VEGF Nanoparticle-Loaded Hyaluronic Acid Hydrogel Author(s): Joanne O’Dwyer, Robert Murphy, Arlyng González-Vázquez, Lenka Kovarova, Martin Pravda, Vladimir Velebny, Andreas Heise, Garry P. Duffy, Sally Ann Cryan Published in: Pharmaceutics, Issue 13/6, 2021, Page(s) 779, ISSN 1999-4923 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/pharmaceutics13060779 Interleukin-1 receptor antagonist enhances the therapeutic efficacy of a low dose of rhBMP-2 in a weight-bearing rat femoral defect model Author(s): Lackington, W.A.; Gehweiler, D.; Zhao, E.; Zderic, I.; Nehrbass, D.; Zeiter, S.; Gonzalez-Vazquez, A.; O'Brien, F.J.; Stoddart, M.J.; Thompson, K. Published in: Acta Biomaterialia, 2022, ISSN 1742-7061 Publisher: Elsevier BV DOI: 10.1016/j.actbio.2022.07.012 Development and in vitro investigation of a biodegradable mesh for the treatment of stress urinary incontinence Author(s): MacCraith, E.; Joyce, M.; do Amaral, R.FJ.C.; O'Brien F.J.; Davis, N.F. Published in: International Urogynecology Journal, 2022, ISSN 1433-3023 Publisher: Springer DOI: 10.1007/s00192-022-05160-2 Highly Porous Type II Collagen-Containing Scaffolds for Enhanced Cartilage Repair with Reduced Hypertrophic Cartilage Formation Author(s): Intini,C.; Hodgkinson, T.; Casey S.M.; Gleeson, J.P.; O'Brien F.J. Published in: Bioengineering, 2022, ISSN 2306-5354 Publisher: MDPI DOI: 10.3390/bioengineering9060232 The development of natural polymer scaffold-based therapeutics for osteochondral repair Author(s): Mark Lemoine, Sarah M. Casey, John M. O'Byrne, Daniel J. Kelly, Fergal J. O'Brien Published in: Biochemical Society Transactions, Issue 48/4, 2020, Page(s) 1433-1445, ISSN 0300-5127 Publisher: Portland Press, Ltd. DOI: 10.1042/bst20190938 Mechanobiology-informed regenerative medicine: Dose-controlled release of placental growth factor from a functionalized collagen-based scaffold promotes angiogenesis and accelerates bone defect healing Author(s): Eamon J. Sheehy, Gregory J. Miller, Isabel Amado, Rosanne M. Raftery, Gang Chen, Kai Cortright, Arlyng Gonzalez Vazquez, Fergal J. O'Brien Published in: Journal of Controlled Release, Issue 334, 2021, Page(s) 96-105, ISSN 0168-3659 Publisher: Elsevier BV DOI: 10.1016/j.jconrel.2021.03.031 The role of mechanobiology in bone and cartilage model systems in characterizing initiation and progression of osteoarthritis Author(s): Hodgkinson, T.; Amado, I.N.; O'Brien F.J.; Kennedy, O.D. Published in: APL Bioengineering, 2021, ISSN 1077-3118 Publisher: AIP Publishing DOI: 10.1063/5.0068277 Evaluation of a co-culture of rapidly isolated chondrocytes and stem cells seeded on tri-layered collagen-based scaffolds in a caprine osteochondral defect model Author(s): Levingstone, T.J.; Sheehy E.J.; Moran, C.J.; Cunniffe, G.M.; Diaz Payno, P.J.; Brady, R.T.; Almeida, H.V.; Carroll, S.F.; Byrne, J.O'M.; Kelly, D.J.; Brama, P.A.J.; O'Brien F.J. Published in: Biomaterials and Biosystems, 2022, ISSN 2666-5344 Publisher: Elsevier DOI: 10.1016/j.bbiosy.2022.100066 Layered Double Hydroxide as a Potent Non-viral Vector for Nucleic Acid Delivery Using Gene-Activated Scaffolds for Tissue Regeneration Applications Author(s): Lara S. Costard, Domhnall C. Kelly, Rachael N. Power, Christopher Hobbs, Sonia Jaskaniec, Valeria Nicolosi, Brenton L. Cavanagh, Caroline M. Curtin, Fergal J. O’Brien Published in: Pharmaceutics, Issue 12/12, 2020, Page(s) 1219, ISSN 1999-4923 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/pharmaceutics12121219 Rapid bone repair with the recruitment of CD206+M2-like macrophages using non-viral scaffold-mediated miR-133a inhibition of host cells Author(s): Irene Mencía Castaño, Rosanne M. Raftery, Gang Chen, Brenton Cavanagh, Brian Quinn, Garry P. Duffy, Fergal J. O'Brien, Caroline M. Curtin Published in: Acta Biomaterialia, Issue 109, 2020, Page(s) 267-279, ISSN 1742-7061 Publisher: Elsevier BV DOI: 10.1016/j.actbio.2020.03.042 Non-viral Gene Delivery of Interleukin-1 Receptor Antagonist Using Collagen-Hydroxyapatite Scaffold Protects Rat BM-MSCs From IL-1β-Mediated Inhibition of Osteogenesis Author(s): William A. Lackington, Maria Antonia Gomez-Sierra, Arlyng González-Vázquez, Fergal J. O’Brien, Martin J. Stoddart, Keith Thompson Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185 Publisher: Frontiers DOI: 10.3389/fbioe.2020.582012 Activation of the SOX‐5, SOX‐6, and SOX‐9 Trio of Transcription Factors Using a Gene‐Activated Scaffold Stimulates Mesenchymal Stromal Cell Chondrogenesis and Inhibits Endochondral Ossification Author(s): Rosanne M. Raftery, Arlyng G. Gonzalez Vazquez, Gang Chen, Fergal J. O'Brien Published in: Advanced Healthcare Materials, Issue 9/10, 2020, Page(s) 1901827, ISSN 2192-2640 Publisher: John Wiley and Sons Ltd DOI: 10.1002/adhm.201901827 Accelerating bone healing in vivo by harnessing the age-altered activation of c-Jun N-terminal kinase 3 Author(s): Arlyng González-Vázquez, Rosanne M. Raftery, Suzan Günbay, Gang Chen, Dylan J. Murray, Fergal J. O'Brien Published in: Biomaterials, Issue 268, 2021, Page(s) 120540, ISSN 0142-9612 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.biomaterials.2020.120540 A highly porous type II collagen containing scaffold for the treatment of cartilage defects enhances MSC chondrogenesis and early cartilaginous matrix deposition Author(s): Intini, C.; Lemoine, M.; Hodgksinon, T.; Casey, S.M.; Gleeson, J.P.; O'Brien F.J. Published in: Biomaterials Science, 2022, ISSN 2047-4849 Publisher: Royal Society of Chemistry DOI: 10.1039/d1bm01417j Incorporation of hydroxyapatite into collagen scaffolds enhances the therapeutic efficacy of rhBMP-2 in a weight-bearing femoral defect model Author(s): Lackington, W.A.; Gehweiler, D.; Zderic, I.; Nehrbass, D.; Zeitar, S.; Gonzalez-Vazquez, A.; O'Brien, F.J.; Stoddart, M.J.; Thopmpson, K. Published in: Materials Today Communications, 2021, ISSN 2352-4928 Publisher: Elsevier BV DOI: 10.1016/j.mtcomm.2021.102933 The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells Author(s): Tom Hodgkinson, P. Monica Tsimbouri, Virginia Llopis-Hernandez, Paul Campsie, David Scurr, Peter G. Childs, David Phillips, Sam Donnelly, Julia A. Wells, Fergal J. O’Brien, Manuel Salmeron-Sanchez, Karl Burgess, Morgan Alexander, Massimo Vassalli, Richard O. C. Oreffo, Stuart Reid, David J. France, Matthew J. Dalby Published in: Science Advances, Issue 7/9, 2021, Page(s) eabb7921, ISSN 2375-2548 Publisher: AAAS DOI: 10.1126/sciadv.abb7921 Articulation inspired by nature: a review of biomimetic and biologically active 3D printed scaffolds for cartilage tissue engineering Author(s): O'Shea, D.G.; Curtin C.M.; O'Brien F.J. Published in: Biomaterials Science, 2022, ISSN 2047-4849 Publisher: Royal Society of Chemistry DOI: 10.1039/d1bm01540k Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis Author(s): Hodgkinson, T.; Kelly, D.C.; Curtin, C.M.; O'Brien F.J. Published in: Nature Reviews Rheumatology, 2021, ISSN 1759-4804 Publisher: Nature Publishing Group DOI: 10.1038/s41584-021-00724-w Systematic Comparison of Biomaterials-Based Strategies for Osteochondral and Chondral Repair in Large Animal Models Author(s): Arlyng G. González Vázquez, Lia A. Blokpoel Ferreras, Kathleen E. Bennett, Sarah M. Casey, Pieter AJ Brama, Fergal J. O'Brien Published in: Advanced Healthcare Materials, 2021, ISSN 2192-2659 Publisher: World Scientific DOI: 10.1002/adhm.202100878 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
