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CoaBC from the Coenzyme A pathway of Mycobacterium tuberculosis as an antimicrobial drug target


Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl- l -cysteine Synthetase (CoaB) Activity

Author(s): Joanna C. Evans, Dinakaran Murugesan, John M. Post, Vitor Mendes, Zhe Wang, Navid Nahiyaan, Sasha L. Lynch, Stephen Thompson, Simon R. Green, Peter C. Ray, Jeannine Hess, Christina Spry, Anthony G. Coyne, Chris Abell, Helena I. M. Boshoff, Paul G. Wyatt, Kyu Y. Rhee, Tom L. Blundell, Clifton E. Barry, Valerie Mizrahi
Published in: ACS Infectious Diseases, Issue 7/6, 2021, Page(s) 1666-1679, ISSN 2373-8227
Publisher: American Chemical Society
DOI: 10.1021/acsinfecdis.0c00904

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site

Author(s): Vitor Mendes, Simon R. Green, Joanna C. Evans, Jeannine Hess, Michal Blaszczyk, Christina Spry, Owain Bryant, James Cory-Wright, Daniel S-H. Chan, Pedro H. M. Torres, Zhe Wang, Navid Nahiyaan, Sandra O’Neill, Sebastian Damerow, John Post, Tracy Bayliss, Sasha L. Lynch, Anthony G. Coyne, Peter C. Ray, Chris Abell, Kyu Y. Rhee, Helena I. M. Boshoff, Clifton E. Barry, Valerie Mizrahi, Paul G. Wyatt
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20224-x

Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility–mass spectrometry

Author(s): Daniel Shiu-Hin Chan, Jeannine Hess, Elen Shaw, Christina Spry, Robert Starley, Claudio Dagostin, Marcio V. B. Dias, Ramesh Kale, Vitor Mendes, Tom L. Blundell, Anthony G. Coyne, Chris Abell
Published in: Biochemical Journal, Issue 476/21, 2019, Page(s) 3125-3139, ISSN 0264-6021
Publisher: Portland Press, Ltd.
DOI: 10.1042/bcj20190318

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