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The Synergistic Merging of Iridium-Catalysed Hydrogen Borrowing and Asymmetric Catalysis in the Pursuit of Enantioenriched Small Molecules

Objective

Hydrogen-borrowing catalysis is a fantastically powerful method of constructing new bonds and synthesising key small organic molecules. However, despite recent advances, many hydrogen-borrowing methodologies do not embrace asymmetric catalysis, limiting its use in targeted synthesis of chiral molecules.
The goal of this proposal is to address these issues and develop new methodologies that involve enantioinduction. In particular,focusing on using hydrogen-borrowing catalysis in combination with forms of asymmetric catalysis (such as organocatalysis) and using hydrogen-borrowing catalysis to transiently activate substrates in order to facilitate reactions that appear unlikely to occur on paper. Following the development of these methodologies, they will be applied to the synthesis of biologically active molecules and natural products.
The high quality and novel research contained within these goals will be met due to the knowledge and experience of the experience researcher and the host, Professor Timothy J. Donohoe, along with the excellent facilities and opportunities afford by the University of Oxford.
Following the completion of the research, the results will be highly interesting and useful to the greater chemistry community in both academia and industry.

Fields of science (EuroSciVoc)

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Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-IF-EF-ST - Standard EF

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-IF-2017

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Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 183 454,80
Address
WELLINGTON SQUARE UNIVERSITY OFFICES
OX1 2JD Oxford
United Kingdom

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 183 454,80
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