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The Synergistic Merging of Iridium-Catalysed Hydrogen Borrowing and Asymmetric Catalysis in the Pursuit of Enantioenriched Small Molecules

Objective

Hydrogen-borrowing catalysis is a fantastically powerful method of constructing new bonds and synthesising key small organic molecules. However, despite recent advances, many hydrogen-borrowing methodologies do not embrace asymmetric catalysis, limiting its use in targeted synthesis of chiral molecules.
The goal of this proposal is to address these issues and develop new methodologies that involve enantioinduction. In particular,focusing on using hydrogen-borrowing catalysis in combination with forms of asymmetric catalysis (such as organocatalysis) and using hydrogen-borrowing catalysis to transiently activate substrates in order to facilitate reactions that appear unlikely to occur on paper. Following the development of these methodologies, they will be applied to the synthesis of biologically active molecules and natural products.
The high quality and novel research contained within these goals will be met due to the knowledge and experience of the experience researcher and the host, Professor Timothy J. Donohoe, along with the excellent facilities and opportunities afford by the University of Oxford.
Following the completion of the research, the results will be highly interesting and useful to the greater chemistry community in both academia and industry.

Call for proposal

H2020-MSCA-IF-2017
See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Address
Wellington Square University Offices
OX1 2JD Oxford
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 183 454,80