Periodic Reporting for period 1 - INBID (Improving the resolution of Neuroinflammation during repetitive mild Traumatic Brain Injury with dietary fatty acid Derivatives)
Reporting period: 2018-11-01 to 2020-10-31
Concussion affects millions of people world-wide each year due to accidents, assaults, domestic violence, contact sports and war. These injuries increase the risk of developing mental health issues such as long-term anxiety and depression and neurodegenerative diseases such as Alzheimer's. Repeated head injury is particularly dangerous. Therefore, understanding the mechanisms that underpin these problems is critical to treating brain injury and disease.
Overall objectives of the work
1) Define the immune-mediated brain inflammation in mouse model of brain injury
2) Develop approaches to promote the resolution of brain inflammation in response to brain injury, with a special focus on dietary lipids as beneficial agents.
This model is currently being used to assess various treatments for disrupted emotional and cognitive behaviour, including the use of different types of diet.
The experiments are ongoing but, if validated, the findings may change the way brain damage is assessed in the clinic after a head injury.
Such translational work would sit at the crossroads of neuroscience and immunology, investigating a brain injury as a cause of mental health issues that may be driven by fundamental immune mechanisms. These neuroimmunological mechanisms will be relevant across a broad range of injury and disease. This may be the foundation of a long-term research program that could change how mild brain injuries are diagnosed and treated.