Periodic Reporting for period 1 - DOPANF (Dopaminergic midbrain modulations by (adaptive) neurofeedback)
Reporting period: 2018-06-01 to 2020-05-31
The second experiment on adaptive neurofeedback control of the dopaminergic midbrain is currently still exploited and will give novel insights into the process of making decisions to exert mental effort dependent on dopaminergic activity. With this, DOPANF aims to achieve a more precise understanding of decision-making and elucidate the exact role of the dopaminergic midbrain in value processing and its impact on effort discounting. Overall, these findings provide a knowledge basis for a better understanding of psychiatric disorders involving the dopaminergic midbrain, such as depression, schizophrenia and addiction.
To achieve the scientific objectives, several efforts in software development have been necessary, which are available as open-source tools for the public:
1) A real-time fMRI neurofeedback toolbox for analysis of the data at the MR facility:
https://econgit.uzh.ch/rt_heroes/rt_fmri_opennft_experiments
2) A behavioral paradigm on decision-making dependent on individual’s brain activity
https://econgit.uzh.ch/ninwie/task_mentaleffortdiscounting_nback
3) A novel analysis approach using graph-theory based analysis for connectivity analysis of real-time fMRI data
https://github.com/lydiatgit/Connectivity_SINGLE
4) A toolbox for data quality assurance of real-time fMRI data (collaboration project)
https://github.com/rtQC-group/rtQC
The exploitation and dissemination of DOPANF in summary:
I attended four conferences and two workshops presenting the project DOPANF.
Two manuscripts as first author are currently under review and preprints are already available. Several other manuscripts I contributed to are also in preparation by colleagues.
I supverised one master project thesis dealing with a novel data analysis approach for DOPANF fMRI data.
I organized or have been invited to four different outreach activities to present my research to the general public.
Two press releases and one YouTube video have been created presenting the project DOPANF.