Objective The aim of this project is to determine the role of natural killer (NK) cells, effector players of the innate immune system that target virally infected cells and tumor cells, in the infectious disease Tick-borne encephalitis (TBE). By elucidating their function either in enhancing or suppressing the disease in two different compartments, central nervous system (CNS) and peripheral blood, we seek to generate knowledge that will provide new insights into innate immunity that could lead to novel strategies to improve treatments for infectious diseases.This project is intended to take place mainly in the Center of Infectious Medicine from the Department of Medicine at Karolinska Institutet (KI) in Stockholm. To complement the scientific training proposed, a secondment of two months will be carried out at the VU University Medical Center in Amsterdam, Netherlands. Overall, the goal of the present application is to support the restart of the scientific formation of the applicant, who has made a 2-year career break due to maternity leave. The short-term objective of the current study is to provide training of the researcher in advanced cellular characterization, labeling, and bio-imaging techniques, synergistically with trans-European mobility, reinforcing her scientific, managerial and leadership qualities. A mid-term objective is the progress of the researcher’s career in science and the broadening of her scientific horizons, and a long-term aim is the Fellow’s setting as an independent investigator. Fields of science natural sciencesbiological sciencesneurobiologymedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicineimmunology Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2017 - Individual Fellowships Call for proposal H2020-MSCA-IF-2017 See other projects for this call Funding Scheme MSCA-IF-EF-CAR - CAR – Career Restart panel Coordinator KAROLINSKA INSTITUTET Net EU contribution € 185 857,20 Address Nobels Vag 5 17177 Stockholm Sweden See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 185 857,20