Objective
Control of tissue size during animal development is of crucial importance to achieve the correct body/organ size and shape, and it underpins the evolution of animal size and architecture. How is tissue size tightly controlled during development? How is each cell in a developing animal instructed to stop growing and dividing when the correct body size and shape has been reached? Answers to these questions are of fundamental importance to our understanding of diseases such as cancer as well as for regenerative medicine. Using the development of the Drosophila abdominal epidermis as a model, we will perform long-term quantitative in vivo analysis of cellular behaviours and generate fluorescent live reporters of growth-promoting pathways to correlate activity patterns with developmentally regulated growth phases. We will manipulate tissue mechanics as well as nutrient-sensing pathways to understand how nutrient availability and tissue-intrinsic physical properties are integrated to specify final tissue size. In combination with computational modelling, we aim to generate a better understanding of developmental growth, as well as the mechanisms that trigger tissue growth arrest. The mechanisms regulating how cell proliferation is triggered in response to extrinsic and intrinsic stimuli and the transitions between different proliferative/growth states, particularly in tumour cells or regenerative tissues, are poorly understood. As these events are precisely defined in Drosophila abdominal morphogenesis, we hope to uncover the internal logic modulating cell cycle/growth rates transitions that can be used as a genetically tractable paradigm for the study of equivalent processes in cancer, regeneration or development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell metabolism
- medical and health sciences clinical medicine oncology
- medical and health sciences clinical medicine embryology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
NW1 1AT London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.