Objective
The plant vasculature comprises the xylem and phloem. The phloem’s conductive cells, the sieve elements, transport sugars produced in leaves to sink organs, such as roots, tubers, fruits and seeds. They also transport hormones and RNAs throughout the plant, enabling its adaptive and continuous development. Individual sieve elements connect through callose-rich sieve plates to form sieve tubes, the larger supra-cellular conducting units. Perforation of the sieve plate with sieve pores is critical to efficient sap flow and can be modulated by callose-mediated occlusion. Indeed, sieve pores are rapidly closed in response to tissues damage, abiotic stresses and infections. Cellular differentiation and adaptation of sieve elements, particularly sieve pore morphogenesis, are surprisingly poorly understood and, lacking powerful cell-biological tools, has largely been neglected. This project sets out to describe a molecular and genetic framework for sieve plate formation. To this end, mutants and transgenic lines already generated in the host lab will be characterized. Additionally, candidate genes, encoding mostly for unknown proteins will be localized in sieve elements. These genes will be functionally characterized using several state-of-the-art methods and specifically-tailored molecular tools, such as inducible CRISPR knock-out, laser ablation and dominant cell-specific genetic interference. This will identify novel molecular players during callose deposition and degradation at sieve pores and advance our mechanistic understanding of sieve plate formation and possible adaptive mechanisms of stress response. Morphological variances and developmental adaptations of sieve pores are important for phloem source-to-sink transport and nearly all calories consumed by humans and livestock have at some point passed through sieve pores. Hence, understanding their morphogenesis at the molecular level is equally relevant for fundamental plant science as for modern agriculture.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA
- natural sciences physical sciences optics laser physics
- natural sciences biological sciences botany
- agricultural sciences agriculture, forestry, and fisheries agriculture horticulture vegetable growing root crops
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.