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Calcium-dependent Lectins in Human Pathogenic Infections: From Atomistic Understanding to Ligand Design

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Induction of rare conformation of oligosaccharide by binding to calcium-dependent bacterial lectin: X-ray crystallography and modelling study

Author(s): Martin Lepsik, Roman Sommer, Sakonwan Kuhaudomlarp, Mickaël Lelimousin, Emanuele Paci, Annabelle Varrot, Alexander Titz, Anne Imberty
Published in: European Journal of Medicinal Chemistry, 177, 2019, Page(s) 212-220, ISSN 0223-5234
Publisher: Elsevier BV
DOI: 10.1016/j.ejmech.2019.05.049

A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d -galactose pentaacetate

Author(s): Eva Zahorska, Sakonwan Kuhaudomlarp, Saverio Minervini, Sultaan Yousaf, Martin Lepsik, Thorsten Kinsinger, Anna K. H. Hirsch, Anne Imberty, Alexander Titz
Published in: Chemical Communications, 2020, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cc03490h