Development of novel inhibitors of the anti-infective target DXS using dynamic combinatorial chemistry (DCC)

Project Information

NovInDXS

Grant agreement ID: 796089

DOI

10.3030/796089

Project closed

EC signature date 13 February 2018

Start date 1 March 2018

End date 26 May 2020

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 171 460,80

EU contribution

€ 171 460,80

Coordinated by

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany

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Publications

Non-peer reviewed articles (1)

Identification of Inhibitors of the Anti-Infective Target DXS Using Dynamic Combinatorial Chemistry

Author(s): Ravindra P. Jumde, Alaa Alhayek, Robin M. Gierse, Anna K. H. Hirsch
Published in: Proceedings, Issue 22/1, 2019, Page(s) 81, ISSN 2504-3900
Publisher: MDPI
DOI: 10.3390/proceedings2019022081

Peer reviewed articles (2)

Inverting Small Molecule–Protein Recognition by the Fluorine Gauche Effect: Selectivity Regulated by Multiple H→F Bioisosterism

Author(s): Patrick Bentler, Klaus Bergander, Constantin G. Daniliuc, Christian Mück‐Lichtenfeld, Ravindra P. Jumde, Anna K. H. Hirsch, Ryan Gilmour
Published in: Angewandte Chemie International Edition, Issue 58/32, 2019, Page(s) 10990-10994, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201905452

Validating the 1,2-Difluoro Motif As a Hybrid Bioisostere of CF 3 and Et Using Matrix Metalloproteinases As Structural Probes

Author(s): Nathalie Erdeljac, Christian Thiehoff, Ravindra P. Jumde, Constantin G. Daniliuc, Sandra Höppner, Andreas Faust, Anna K. H. Hirsch, Ryan Gilmour
Published in: Journal of Medicinal Chemistry, Issue 63/11, 2020, Page(s) 6225-6237, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c00648

Other (2)

Enhancing Glycan Stability via Site-Selective Fluorination: Modulating Substrate Orientation by Molecular Design.

Author(s): Alexander Axer, Ravindra P. Jumde, Sebastian Adam, Andreas Faust, Michael Schäfers, Manfred Fobker, Jesko Koehnke, Anna K.H. Hirsch, Ryan Gilmour
Published in: ChemRxiv, 2020
Publisher: ChemRxiv
DOI: 10.26434/chemrxiv.12656210.v1

Hit-Optimization Using Target-Directed Dynamic Combinatorial Chemistry: Development of Inhibitors of the Anti-Infective Target 1-Deoxy-D-Xylulose-5-Phosphate Synthase

Author(s): Ravindra P. Jumde, Melissa Guardigni, Robin M. Gierse, Alaa Alhayek, Di Zhu, Zhoor Hamed, Sandra Johannsen, Walid A. M. Elgaher, Jörg Haupenthal, Anna K.H. Hirsch
Published in: ChemRxiv, 2020
Publisher: ChemRxiv
DOI: 10.26434/chemrxiv.12681761.v1