Objective
Spectro-Metrics focuses on the development and validation of advanced chemometric procedures for investigating drug intake and metabolism in cells using confocal Raman micro Spectroscopy (RS). The project will develop and optimize data mining procedures such as Multivariate Curve Resolution-Alternate Least Squares (MCR-ALS), Supported Vector Machines (SVM) and Science Based Calibration (SBC) for the extraction of biologically relevant information from RS of cells. The applicability of the procedures will be thoroughly validated in vitro including studies on the effect of drug concentration, incubation time and drug distribution within cells. Research activities will include the use of simulated and real spectroscopic data obtained from in vitro studies for investigating the effect of inoculation with the commercial drugs, doxorubicin (DOX) and actinomycin (ACT) in lung cancer cells, as a function of time and dose, as model systems. Upon completion, the project will produce validated methodologies and procedures for resolving Raman spectra which will lead to the elucidation of the modes of drug action and validation of Raman as a preclinical screening technique for drug design and discovery. The knowledge, grant writing skills and publication record acquired during the fellowship will place the Experienced Researcher (ER) in an invaluable position for achieving research independence, becoming a leading expert of chemometric treatment of RS data and eventually becoming a professor in one of the leading European universities in the field of clinical spectroscopy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine medicinal chemistry
- medical and health sciences clinical medicine oncology lung cancer
- natural sciences computer and information sciences data science data mining
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
D07 EWV4 Dublin
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.