Periodic Reporting for period 2 - INMARE (Injectable hydrogels for magnetically-activated, remote-controlled drug delivery)
Période du rapport: 2021-01-22 au 2022-01-21
Regarding the conclusions of the action, the key goals of the INMARE project were successfully achieved:
a) A strong a through training of myself in the science, technology and industrial applications of magnetic nanomaterials and drug delivery systems at Stanford University and the host group at University of the Basque Country.
b) I designed, fabricated and developed advanced drug delivery systems. In addition to that, I contributed substantially to the understanding of the Physics behind diffusion in these type of drug delivery systems, by formulating the most accurate predictive model for solute diffusion in hydrogels to date.
The work performed from the beginning of the project and the main results achieved, together with the dissemination of the results are listed here:
1) Understanding of the physics behind mass diffusion in biomaterials.
Dissemination:
A Multiscale Model for Solute Diffusion in Hydrogels
Eneko Axpe, Doreen Chan, Giovanni S. Offeddu, Yin Chang, David Merida, Hector Lopez Hernandez, and Eric A. Appel
Macromolecules, 2019
https://pubs.acs.org/doi/abs/10.1021/acs.macromol.9b00753
Eneko Axpe. A multiscale model for solute diffusion in hydrogels. Materials Research Society – Fall
Meeting and Exhibit, 2019, Boston, USA (Oral presentation)
2) Understanding of the physics behind diffusion and mechanical properties in biomaterials for drug delivery in brain.
Dissemination:
Towards brain-tissue-like biomaterials
Eneko Axpe, Gorka Orive, Kristian Franze & Eric A. Appel
Nature Communications, 2020
https://www.nature.com/articles/s41467-020-17245-x
3) Developed an injectable hydrogel for sustained delivery of vaccines.
Injectable hydrogels for sustained codelivery of subunit vaccines enhance humoral immunity
Authors
Gillie A Roth, Emily C Gale, Marcela Alcántara-Hernández, Wei Luo, Eneko Axpe, Rohit Verma, Qian Yin, Anthony C Yu, Hector Lopez Hernandez, Caitlin L Maikawa, Anton AA Smith, Mark M Davis, Bali Pulendran, Juliana Idoyaga, Eric A Appel
ACS Central Science, 2020
https://pubs.acs.org/doi/abs/10.1021/acscentsci.0c00732
Eneko Axpe. Injectable hydrogels for bone regeneration. NASA Human Research Program Investigators
Workshop, 2019, Galveston, USA (Invited oral presentation)
4) Developed a hydrogel for preventing biofouling on implantable biosensors.
Dissemination:
Combinatorial polyacrylamide hydrogels for preventing biofouling on implantable biosensors
Authors
Doreen Chan, Jun-Chau Chien, Eneko Axpe, Louis Blankemeier, Samuel W Baker, Sarath Swaminathan, Victoria A Piunova, Dmitry Yu Zubarev, Caitlin L Maikawa, Abigail K Grosskopf, Joseph L Mann, H Tom Soh, Eric A Appel
https://web.archive.org/web/20210429021027id_/https://www.biorxiv.org/content/biorxiv/early/2020/12/18/2020.05.25.115675.full.pdf
I also created, together with my team, a drug delivery system that offers sustained vaccine delivery. This biomaterial, if widely used in the future, could improve the efficacy of vaccines in millions of people by preventing from spikes in dosing and giving the patient a controlled vaccine delivery that it has been proven to increase humoral immunity in animal models.
I have also developed, together with my team, a biomaterial that could be use as a coating material to prevent fouling in implanted medical devices. This could have a huge impact in making the lifespan of implanted biomedical devices longer in millions of patients.