Objective
Cellular protein homeostasis (proteostasis) is central to health and disease status. It depends on complex regulatory networks of two major interconnected proteolytic degradation pathways: the ubiquitin-proteasome (UPS) and autophagy systems. Here we will investigate whether a novel proteostasis pathway, called the Intracellular Pathogen Response (IPR), recently identified in the model system Caenorhabditis elegans, is also active in mammalian cells. In C. elegans the IPR is upregulated during infection by Microsporidia, a highly successful group of obligate intracellular parasites that infect a broad range of invertebrates and mammals, including humans. Very little is currently known about mammalian intracellular responses to Microsporidia infections. The objective of the project is to dissect the mammalian proteostasis response to Microsporidia infections and compare it to the IPR from C. elegans. To accomplish this a multidisciplinary approach combining genetics, cell biology and proteomics will be applied to Microsporidia-mammalian models developed in the host lab. The proposal involves a promising French researcher with a background in invertebrate parasitology and host responses to infection, moving to a host laboratory in Newcastle, UK, noted for excellent training of young researchers, and for its research on Microsporidia molecular cell biology. Training in analysing Microsporidia infection dynamics in mammalian cells will be supported by host training in dissecting cellular proteostasis pathways to synergistically complement the skills of the researcher in invertebrate parasitology. The project will equip the researcher with strong expertise in molecular cell biology from a comparative perspective. It will also deliver the first detailed insights into the mammalian UPS/autophagy response to Microsporidia infection, with general implications for understanding mammalian proteostasis in health and disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences health sciences parasitology
- natural sciences biological sciences cell biology
- medical and health sciences basic medicine physiology homeostasis
- natural sciences biological sciences zoology invertebrate zoology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
NE1 7RU Newcastle Upon Tyne
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.