Objective
It is estimated that the incidence of diabetes in Europe will affect 43 million people by 2030. 15% of diabetic patients develop a diabetic foot ulcer (DFU) with 14-24% of these patients requiring amputation. Mortality following amputation of 50–68% is comparable or worse than for most malignancies. My strategy will develop for the first time a skin substitute which combines a biopolymer and a functionalized synthetic FDA approved polymer incorporating bioactive components and AgO and ZnO nanoparticles as antibacterial agents. The cellular compatibility of the hybrid skin substitute will be assessed on fibroblast, keratinocyte and hMSC in a 3D cell culture model. The antimicrobial efficacy will be assessed in vitro and in vivo. The optimised scaffold will be assessed in an alloxan-induced diabetic rabbit ulcer model with gold standards Integra® and Alloderm® skin grafts acting as commercial controls to validate the commercial potential of the technology. Progress to completion will be reviewed by a Research and Professional Development Plan which will provide both discipline-specific and complementary technical training (molecular biology, diabetic wound healing in vivo models, and histological and stereological techniques) and generic and complementary transferable skills training (e.g. intellectual property, leadership skills, motivation skills, communication skills, leveraging non-exchequer funding, regulatory affairs, clinical trial design, reimbursement strategies, medical device evaluation and regulatory affairs). I will benefit from Prof Pandit’s and Prof Dulce Papy-Garcia (secondment) international collaborative network in the field of diabetic wound healing. This training will facilitate me to achieve my future career goals of achieving a position of professional maturity, diversity and independence by establishing my own research group at a leading European institution and enabling me to translate innovative therapeutic interventions to the clinic setting.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences chemical sciences polymer sciences
- engineering and technology nanotechnology nano-materials
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
H91 Galway
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.