Periodic Reporting for period 1 - Rotaxane-DNA (Rotaxane-Oligonucleotides: Stimuli-Responsive Mechanically Interlocked Architectures to Control Oligonucleotide Activity and Gene Transcription)
Reporting period: 2018-06-07 to 2020-10-06
The results of this study formed the basis of a successful application for further funding which will be used to take these new molecules towards applications in chemical biology. The work also formed the basis of a publication in J. Am. Chem. Soc. and several presentations at national meetings in the UK.
In future, my hosts will develop these methods further to incorporate RNA in place of DNA and systems in which the effect of the ring can be controlled. The work during this MCSA provides a foundation for these future developments as I have demonstrated the long term potential of rotaxane-oligonucleotides for a cross section of current synthetic oligonucleotide applications and drive future applications of these materials towards a versatile platform for chemical biology.