Objective
Group 2 innate lymphoid cells (ILC2) are strategically positioned at mucosal surfaces, regulating mucosal defense, tissue homeostasis and inflammation. ILC2 contribute to the pathogenesis of allergic airway diseases, and pulmonary neurons have been also implicated in allergic conditions, such as asthma. Interestingly, recent studies demonstrated that ILC2 exert their function in the context of neuro-immune cell units that respond to environmental signals, steering mucosal immunity and repair. Nevertheless, the identity of the neuronal circuits innervating neuro-immune cell units and the nature of the bidirectional neuron-immune signals steering mucosal physiology remain elusive. Here, we hypothesize that pulmonary neuronal circuits provide and receive signals from ILC2, which steer immune responses in airway inflammation and infection.
Initially we will use transgenic animals, engineered rabies virus and advanced imaging techniques to functionally map the innervation of neuron-ILC2 units. Sequentially, we will employ a combination of genetic, cellular and molecular approaches to determine how efferent neuronal activity controls pulmonary ILC2 biology and how ILC2-mediated effects impact on neuronal activity to maintain tissue homeostasis in the context of allergy and infection.
Under this fellowship, we aim to establish how the interplay between neurons and immune cells steers tissue homeostasis. By identifying these new pathways, this action will contribute to the development of new therapeutic strategies in mucosal diseases that affect millions of people worldwide. Simultaneously, the fellowship will importantly strengthen the experienced researcher’s knowledge, skills and network to allow him to establish himself as an independent researcher.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine pneumology asthma
- natural sciences biological sciences microbiology virology
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine allergology
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1400-038 LISBOA
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.