The Dynamic Composition of the Protein Chaperone Network: Unraveling Human Protein Disaggregation via NMR Spectroscopy

Project Information

NMR-DisAgg

Grant agreement ID: 802001

DOI

10.3030/802001

Project closed

EC signature date 6 August 2018

Start date 1 September 2018

End date 31 August 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 956,00

EU contribution

€ 1 499 956,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

Hsp104 N-terminal domain interaction with substrates plays a regulatory role in protein disaggregation

Author(s): Harari Anna, Zoltsman Guy, Levin Tal, Rosenzweig Rina.
Published in: FEBS J., 2022, ISSN 1742-4658
Publisher: FEBS - Wiley Online Library
DOI: 10.1111/febs.16441

DNAJB6 mutants display toxic gain of function through unregulated interaction with Hsp70 chaperones

Author(s): Meital Abayev-Avraham, Yehuda Salzberg, Dar Gliksberg, Meital Oren-Suissa, and Rina Rosenzweig
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-42735-z

HSP40 proteins use class-specific regulation to drive HSP70 functional diversity

Author(s): Ofrah Faust, Meital Abayev-Avraham, Anne S. Wentink, Michael Maurer, Nadinath B. Nillegoda, Nir London, Bernd Bukau, Rina Rosenzweig
Published in: Nature, Issue 587/7834, 2020, Page(s) 489-494, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2906-4

NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems

Author(s): Maximilian M Biebl, Florent Delhommel, Ofrah Faust, Krzysztof M Zak, Ganesh Agam, Xiaoyan Guo , Moritz Mühlhofer, Vinay Dahiya, Daniela Hillebrand, Grzegorz M Popowicz, Martin Kampmann, Don C Lamb, Rina Rosenzweig, Michael Sattler, Johannes Buchner
Published in: Molecular Cell, Issue 82, 2022, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.12.031

Hsp40s play complementary roles in the prevention of tau amyloid formation

Author(s): Rose Irwin, Ofrah Faust, Ivana Petrovic, Sharon Grayer Wolf, Hagen Hofmann, Rina Rosenzweig
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.69601

Book chapters (2)

Structural and Biochemical Properties of Hsp40/Hsp70 Chaperone System.

Author(s): Ofrah Faust; Rina Rosenzweig
Published in: Advances in Experimental Medicine and Biology - HSF1 and Molecular Chaperones in Biology and Cancer, Issue 2, 2020
Publisher: Springer
DOI: 10.1007/978-3-030-40204-4_1

Structural and Biochemical Properties of Hsp40/Hsp70 Chaperone System

Author(s): Ofrah Faust, Rina Rosenzweig
Published in: HSF1 and Molecular Chaperones in Biology and Cancer, Issue 1243, 2020, Page(s) 3-20, ISBN 978-3-030-40203-7
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-40204-4_1