Objective
Atomic resolution microscopy relies on beams of energetic electrons. These beams quickly destroy fragile materials, making imaging them a major challenge. I have recently developed a new approach that provides the greatest possible resolving power per electron. The method provides both double resolution and excellent noise rejection, via multidimensional data acquisition and analysis. Here I propose to couple the new method with breakthroughs in high speed cameras to achieve unprecedented clarity at low doses, almost guaranteeing major advances for imaging beam sensitive materials. Proof of principle will be achieved for biochemical imaging using the easy to handle, commercially available GroEL chaperone molecule. We will combine our enhanced imaging capabilities with the averaging methods recently recognized by the Nobel prize in chemistry for imaging biomolecules at ultra low doses. After proving our low dose capabilities we will apply them to imaging proteins of current interest at greater resolution. Similar techniques will be used for fragile materials science samples, for instance metal organic framework, Li ion battery, 2D, catalyst and perovskite solar cell materials. Furthermore the same reconstruction algorithms can be applied to simultaneously acquired spectroscopic images, allowing us to not only locate all the atoms, but identify them. The properties of all materials are determined by the arrangement and identity of their atoms, and therefore our work will impact all major areas of science, from biology to chemistry and physics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors optical sensors
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy
- natural sciences chemical sciences catalysis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-STG - Starting Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2018-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2000 Antwerpen
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.