Objective Atomic resolution microscopy relies on beams of energetic electrons. These beams quickly destroy fragile materials, making imaging them a major challenge. I have recently developed a new approach that provides the greatest possible resolving power per electron. The method provides both double resolution and excellent noise rejection, via multidimensional data acquisition and analysis. Here I propose to couple the new method with breakthroughs in high speed cameras to achieve unprecedented clarity at low doses, almost guaranteeing major advances for imaging beam sensitive materials. Proof of principle will be achieved for biochemical imaging using the easy to handle, commercially available GroEL chaperone molecule. We will combine our enhanced imaging capabilities with the averaging methods recently recognized by the Nobel prize in chemistry for imaging biomolecules at ultra low doses. After proving our low dose capabilities we will apply them to imaging proteins of current interest at greater resolution. Similar techniques will be used for fragile materials science samples, for instance metal organic framework, Li ion battery, 2D, catalyst and perovskite solar cell materials. Furthermore the same reconstruction algorithms can be applied to simultaneously acquired spectroscopic images, allowing us to not only locate all the atoms, but identify them. The properties of all materials are determined by the arrangement and identity of their atoms, and therefore our work will impact all major areas of science, from biology to chemistry and physics. Fields of science engineering and technologyenvironmental engineeringenergy and fuelsrenewable energysolar energynatural scienceschemical scienceselectrochemistryelectric batteriesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesphysical sciencesopticsmicroscopyelectron microscopynatural scienceschemical sciencescatalysis Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-2018-STG - ERC Starting Grant Call for proposal ERC-2018-STG See other projects for this call Funding Scheme ERC-STG - Starting Grant Coordinator UNIVERSITEIT ANTWERPEN Net EU contribution € 1 130 164,69 Address Prinsstraat 13 2000 Antwerpen Belgium See on map Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Beneficiaries (3) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITEIT ANTWERPEN Belgium Net EU contribution € 1 130 164,69 Address Prinsstraat 13 2000 Antwerpen See on map Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Participation ended Germany Net EU contribution € 0,00 Address Hofgartenstrasse 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAT WIEN Austria Net EU contribution € 369 835,31 Address Universitatsring 1 1010 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
