Periodic Reporting for period 1 - InsideChromatin (Towards Realistic Modelling of Nucleosome Organization Inside Functional Chromatin Domains)
Reporting period: 2019-04-01 to 2020-09-30
InsideChromatin aims to develop a groundbreaking multiscale approach that will push the current limits of realistic computational modelling of in vivo chromatin structure. The vision is to achieve the first multiscale
simulation study that resolves nucleosome organization inside structurally different Kb-scale domains, while accounting with atomistic resolution for the combination of epigenetic marks, architectural proteins, and nucleosome remodelling activity that distinguishes each domain. InsideChromatin will integrate atomistic simulations with two levels of coarse-graining and experimental data for validation to bridge nucleosome organization to physical properties in Mb-scale domains. InsideChromatin aims to bring us closer to the ‘holy grail’ of deciphering the connection between genome characteristics, structure, and function.