Epigenetic fine-tuning of T cells for improved adoptive cell therapy

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Matching or genetic engineering of HLA Class I and II facilitates successful allogeneic ‘off-the-shelf’ regulatory T cell therapy

Author(s): Oliver McCallion, Weijie Du, Viktor Glaser, Kate Milward, Clemens Franke, Jonas Kath, Mikhail Valkov, Mingxing Yang, Annette Künkele, Julia K. Polansky, Michael Schmueck-Henneresse, Hans-Dieter Volk, Petra Reinke, Dimitrios L. Wagner, Joanna Hester, Fadi Issa
Published in: 2023
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.08.06.551956

Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases

Author(s): Carina Saggau, Petra Bacher, Daniela Esser, Mahdi Rasa, Silja Meise, Nicola Mohr, Nora Kohlstedt, Andreas Hutloff, Sarah-Sophie Schacht, Justina Dargvainiene, Gabriela Rios Martini, Klarissa H. Stürner, Ina Schröder, Robert Markewitz, Johannes Hartl, Maria Hastermann, Ankelien Duchow, Patrick Schindler, Mareike Becker, Carolin Bautista, Judith Gottfreund, Jörn Walter, Julia K. Polansky, Mingxin
Published in: Immunity, Issue 57, 2025, Page(s) 2416-2432.e8, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2024.08.005

Targeted De-Methylation of the FOXP3-TSDR Is Sufficient to Induce Physiological FOXP3 Expression but Not a Functional Treg Phenotype

Author(s): Christopher Kressler, Gilles Gasparoni, Karl Nordström, Dania Hamo, Abdulrahman Salhab, Christoforos Dimitropoulos, Sascha Tierling, Petra Reinke, Hans-Dieter Volk, Jörn Walter, Alf Hamann, Julia K. Polansky
Published in: Frontiers in Immunology, Issue 11, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2020.609891

Effector memory–type regulatory T cells display phenotypic and functional instability

Author(s): Désirée Jacqueline Wendering, Leila Amini, Stephan Schlickeiser, Martí Farrera-Sal, Sarah Schulenberg, Lena Peter, Marco Mai, Tino Vollmer, Weijie Du, Maik Stein, Frederik Hamm, Alisier Malard, Carla Castro, Mingxing Yang, Ramon Ranka, Timo Rückert, Pawel Durek, Frederik Heinrich, Gilles Gasparoni, Abdulrahman Salhab, Jörn Walter, Dimitrios Laurin Wagner, Mir-Farzin Mashreghi, Sybille Landweh
Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548
Publisher: Science
DOI: 10.1126/sciadv.adn3470

Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function

Author(s): Kristy Ou, Dania Hamo, Anne Schulze, Andy Roemhild, Daniel Kaiser, Gilles Gasparoni, Abdulrahman Salhab, Ghazaleh Zarrinrad, Leila Amini, Stephan Schlickeiser, Mathias Streitz, Jörn Walter, Hans-Dieter Volk, Michael Schmueck-Henneresse, Petra Reinke, Julia K. Polansky
Published in: Frontiers in Cell and Developmental Biology, Issue 9, 2023, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2021.751590

Gene editing of CD3 epsilon to redirect regulatory T cells for adoptive T cell transfer

Author(s): Weijie Du, Fatih Noyan, Oliver McCallion, Vanessa Drosdek, Jonas Kath, Viktor Glaser, Carla Fuster-Garcia, Mingxing Yang, Maik Stein, Clemens Franke, Yaolin Pu, Olaf Weber, Julia K. Polansky, Toni Cathomen, Elmar Jaeckel, Joanna Hester, Fadi Issa, Hans-Dieter Volk, Michael Schmueck-Henneresse, Petra Reinke, Dimitrios L. Wagner
Published in: Molecular Therapy, Issue 33, 2025, Page(s) 997-1013, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2025.01.045

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