Periodic Reporting for period 3 - 3D-nanoMorph (Label-free 3D morphological nanoscopy for studying sub-cellular dynamics in live cancer cells with high spatio-temporal resolution)
Reporting period: 2022-07-01 to 2023-12-31
The overall objectives are
• To kick-start a new research field at the nexus of nanoscopy and non-linear inverse scattering.
• To harness the advantages of non-linear inverse scattering into the field of label free nanoscopy, overcoming the long-standing limitations of diffraction barrier.
• To demonstrate 3D-nanoMorph’s immense utility in biology and life-sciences by imaging the degradation of sub-cellular organelles in real-time during autophagy in cancer cells, opening up new possibilities for cancer research.
3D-nanoMorph’s objectives will be achieved through devising a novel imaging system, developing novel inverse scattering algorithm, and applying the technology for imaging autophagy of live cancer cells.