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A synergistic approach toward understanding receptor signaling in the cell at very high resolution

Project description

Investigating receptors in their cellular environment at atomic-level resolution

Members of the epidermal growth factor receptor family (EGFRs) regulate cell growth and proliferation and are implicated in all phases of tumour progression. The EU-funded HighResCells project is taking an interdisciplinary approach and using EGFRs as a model system to study their conformational and oligomeric states, bound ligands and signal transduction molecules in different activation states at atomic resolution in situ. The research will elucidate the properties of the EGFRs across a wide range of complexity in the cellular environment through their high-resolution structures and changes during receptor recycling. The developed technology will help take structural biology research to the next level, enabling atomic-resolution description of receptors in their cellular environment.

Call for proposal

ERC-2018-SyG
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Host institution

UNIVERSITAT ZURICH
Address
Ramistrasse 71
8006 Zurich
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 4 774 500

Beneficiaries (3)

UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 4 774 500
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 1 772 500
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 1 726 457
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations