Investigating receptors in their cellular environment at atomic-level resolution
Members of the epidermal growth factor receptor family (EGFRs) regulate cell growth and proliferation and are implicated in all phases of tumour progression. The EU-funded HighResCells project is taking an interdisciplinary approach and using EGFRs as a model system to study their conformational and oligomeric states, bound ligands and signal transduction molecules in different activation states at atomic resolution in situ. The research will elucidate the properties of the EGFRs across a wide range of complexity in the cellular environment through their high-resolution structures and changes during receptor recycling. The developed technology will help take structural biology research to the next level, enabling atomic-resolution description of receptors in their cellular environment.
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