Molecular Signaling in Health and Disease - Interdisciplinary Centre of Excellence

Project Information

MOSaIC

Grant agreement ID: 810425

DOI 10.3030/810425

Project closed

EC signature date 29 May 2018

Start date 1 November 2018

End date 31 October 2023

Funded under

• Establishing ‚ERA Chairs’

Total cost € 2 498 887,50

EU contribution € 2 498 887,50

Coordinated by

MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ W WARSZAWIE
Poland

Deliverables

Documents, reports (13)

Reports from specialized training sessions
Reports from exchange visits
IIMCB annual reports promoting the project
Programmes of career development training sessions
Abstracts/posters from in-house seminars of renowned experts and the final conference

Abstractsposters from inhouse seminars of renowned experts and the final conference

OA publications
Abstracts/posters from European and overseas scientific conferences

Abstractsposters from European and overseas scientific conferences

OA policy
Report on a new course in Warsaw-4-PhD curriculum provided by IIMCB researchers

Report on a new course in Warsaw4PhD curriculum provided by IIMCB researchers

Programme of a workshop on gender issues
Reports/s on open workshop/s on OA, ODM, and ethics

Reportss on open workshops on OA ODM and ethics

Gender Equality Plan for IIMCB

Gender Equality Plan for IIMCB established

ODM policy

Other (1)

List of project proposals submitted to Polish and international funding sources

Websites, patent fillings, videos etc. (2)

Links to MOSaIC, the new laboratory, and social media websites

Links to MOSaIC the new laboratory and social media websites

Samples of MOSaIC's promotional materials

Samples of MOSaICs promotional materials

Publications

Peer reviewed articles (17)

Landscape of functional interactions of human processive ribonucleases revealed by high-throughput siRNA screenings

Author(s): Anna Hojka-Osinska; Aleksander Chlebowski; Joanna Grochowska; Ewelina P. Owczarek; Kamila Affek; Kamila Kłosowska-Kosicka; Roman J. Szczesny; Andrzej Dziembowski
Published in: iScience, Vol 24, Iss 9, Pp 103036- (2021), Issue 2, 2021, ISSN 2589-0042
Publisher: ScienceDirect
DOI: 10.1016/j.isci.2021.103036

Three-layered control of mRNA poly(A) tail synthesis in <i>Saccharomyces cerevisiae</i>

Author(s): Matti Turtola; M. Cemre Manav; Ananthanarayanan Kumar; Agnieszka Tudek; Seweryn Mroczek; Paweł S. Krawczyk; Andrzej Dziembowski; Manfred Schmid; Lori A. Passmore; Ana Casañal; Torben Heick Jensen
Published in: Genes & Development, Issue 2, 2021, ISSN 1549-5477
Publisher: Cold Spring Harbor Laboratory Press in association with The Genetics Society
DOI: 10.1101/gad.348634.121

Functions and mechanisms of RNA tailing by metazoan terminal nucleotidyltransferases

Author(s): Vladyslava Liudkovska, Andrzej Dziembowski
Published in: Wiley Interdisciplinary Reviews: RNA, Issue 12(2), 2020, ISSN 1757-7004
Publisher: John Wiley and Sons Inc.
DOI: 10.1002/wrna.1622

SupeRNAlign: a new tool for flexible superposition of homologous RNA structures and inference of accurate structure-based sequence alignments

Author(s): Paweł Piątkowski, Jagoda Jabłońska, Adriana Żyła, Dorota Niedziałek, Dorota Matelska, Elżbieta Jankowska, Tomasz Waleń, Wayne K. Dawson, Janusz M. Bujnicki
Published in: Nucleic Acids Research, Issue 45/16, 2017, Page(s) e150-e150, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkx631

Retro-translocation of mitochondrial intermembrane space proteins

Author(s): Piotr Bragoszewski, Michal Wasilewski, Paulina Sakowska, Agnieszka Gornicka, Lena Böttinger, Jian Qiu, Nils Wiedemann, Agnieszka Chacinska
Published in: Proceedings of the National Academy of Sciences, Issue 112/25, 2015, Page(s) 7713-7718, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1504615112

On the role of steric clashes in methylation control of restriction endonuclease activity

Author(s): Karolina Mierzejewska, Matthias Bochtler, Honorata Czapinska
Published in: Nucleic Acids Research, Issue 44/1, 2016, Page(s) 485-495, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkv1341

Redundans: an assembly pipeline for highly heterozygous genomes

Author(s): Leszek P. Pryszcz, Toni Gabaldón
Published in: Nucleic Acids Research, Issue 44/12, 2016, Page(s) e113-e113, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkw294

SimRNAweb: a web server for RNA 3D structure modeling with optional restraints

Author(s): Marcin Magnus, Michał J. Boniecki, Wayne Dawson, Janusz M. Bujnicki
Published in: Nucleic Acids Research, Issue 44/W1, 2016, Page(s) W315-W319, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkw279

Coordination between the polymerase and RNase H activity of HIV-1 reverse transcriptase

Author(s): Małgorzata Figiel, Miroslav Krepl, Jarosław Poznański, Agnieszka Gołąb, Jiří Šponer, Marcin Nowotny
Published in: Nucleic Acids Research, 2017, Page(s) gkx004, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkx004

Modeling of ribonucleic acid-ligand interactions

Author(s): Filip Stefaniak, Ewa I. Chudyk, Michael Bodkin, Wayne K. Dawson, Janusz M. Bujnicki
Published in: Wiley Interdisciplinary Reviews: Computational Molecular Science, Issue 5/6, 2015, Page(s) 425-439, ISSN 1759-0876
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/wcms.1226

Chatty Mitochondria: Keeping Balance in Cellular Protein Homeostasis

Author(s): Ulrike Topf, Lidia Wrobel, Agnieszka Chacinska
Published in: Trends in Cell Biology, Issue 26/8, 2016, Page(s) 577-586, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2016.03.002

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

Author(s): Lidia Wrobel, Ulrike Topf, Piotr Bragoszewski, Sebastian Wiese, Malgorzata E. Sztolsztener, Silke Oeljeklaus, Aksana Varabyova, Maciej Lirski, Piotr Chroscicki, Seweryn Mroczek, Elzbieta Januszewicz, Andrzej Dziembowski, Marta Koblowska, Bettina Warscheid, Agnieszka Chacinska
Published in: Nature, Issue 524/7566, 2015, Page(s) 485-488, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature14951

NPDock: a web server for protein–nucleic acid docking

Author(s): Irina Tuszynska, Marcin Magnus, Katarzyna Jonak, Wayne Dawson, Janusz M. Bujnicki
Published in: Nucleic Acids Research, Issue 43/W1, 2015, Page(s) W425-W430, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkv493

Sequence-specific cleavage of dsRNA by Mini-III RNase

Author(s): Dawid Głów, Dariusz Pianka, Agata A. Sulej, Łukasz P. Kozłowski, Justyna Czarnecka, Grzegorz Chojnowski, Krzysztof J. Skowronek, Janusz M. Bujnicki
Published in: Nucleic Acids Research, Issue 43/5, 2015, Page(s) 2864-2873, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkv009

A long noncoding RNA promotes parasite differentiation in African trypanosomes.

Author(s): Fabien Guegan; K. Shanmugha Rajan; Fábio Bento; Daniel Pinto-Neves; Mariana Sequeira; Natalia Gumińska; Seweryn Mroczek; Andrzej Dziembowski; Smadar Cohen-Chalamish; Tirza Doniger; Beathrice Galili; Antonio M. Estévez; Cedric Notredame; Shulamit Michaeli; Luisa M. Figueiredo
Published in: Crossref, Issue VOL. 8, NO. 24, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abn2706

TENT5 cytoplasmic noncanonical poly(A) polymerases regulate the innate immune response in animals

Author(s): Liudkovska V, Krawczyk PS, Brouze A, Gumińska N, Wegierski T, Cysewski D, Mackiewicz Z, Ewbank JJ, Drabikowski K, Mroczek S, Dziembowski A
Published in: Science Advances, Issue Vol 8, Issue 46, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.add9468

Global view on the metabolism of RNA poly(A) tails in yeast Saccharomyces cerevisiae

Author(s): Agnieszka Tudek; Katarzyna Matylla-Kulińska; Pawel S Krawczyk; Torben Heick Jensen; Andrzej Dziembowski; Rafal Tomecki; Matti Turtola; Seweryn Mroczek
Published in: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021), Issue 1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25251-w

Other (5)

Mutation in mitochondrial chaperone TRAP1 results in male-specific autism

Author(s): Małgorzata Rydzanicz, Bozena Kuzniewska, Marta Magnowska, Tomasz Wójtowicz, Ewa Borsuk, Olga Gewartowska, Jakub Gruchota, Anna Hojka, Jacek Miłek, Aleksandra Stawikowska, Patrycja Wardaszka, Izabela Chojnicka, Ludwika Kondrakiewicz, Alicja Puścian, Ewelina Knapska, Andrzej Dziembowski, Rafał Płoski, Magdalena Dziembowska
Published in: Biorxiv, Issue June 06, 2023, 2023
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.06.02.543381

Polyadenylation of mRNAs encoding secreted proteins by TENT5 family of enzymes is essential for gametogenesis in mice

Author(s): Michał Brouze, Agnieszka Czarnocka-Cieciura, Olga Gewartowska, Monika Kusio-Kobiałka, Kamil Jachacy, Marcin Szpila, Bartosz Tarkowski, Jakub Gruchota, Paweł Krawczyk, Seweryn Mroczek, Ewa Borsuk, Andrzej Dziembowski
Published in: Biorxiv, Issue August 03, 2023, 2023
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.08.01.551432

SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune response

Author(s): Pawel S Krawczyk, Olga Gewartowska, Michal Mazur, Wiktoria Orzel, Katarzyna Matylla-Kulinska, Sebastian Jelen, Pawel Turowski, Tomasz Spiewla, Bartosz Tarkowski, Agnieszka Tudek, Aleksandra Brouze, Aleksandra Wesolowska, Dominika Nowis, Jakub Golab, Joanna Kowalska, Jacek Jemielity, Andrzej Dziembowski, Seweryn Mroczek
Published in: Biorxiv, Issue December 16, 2022, 2022
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.12.01.518149

Multiple Myeloma associated DIS3 mutations drive AID-dependent IgH Translocations

Author(s): 2. Tomasz M. Kuliński, Olga Gewartowska, Mélanie Mahé, Karolina Kasztelan, Janina Durys, Bertrand Séraphin, Andrzej Dziembowski
Published in: Biorxiv, Issue July 27, 2023, 2023
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.07.27.550610

Somatic DIS3 mutations in Multiple Myeloma arise early in clonal evolution, but are later counterselected due to toxicity

Author(s): Tomasz M. Kuliński, Olga Gewartowska, Seweryn Mroczek, Marcin Szpila, Katarzyna Sałas, Vladyslava Liudkovska, Andrzej Dziembowski
Published in: Biorxiv, Issue December 12, 2023, 2023
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.07.27.550471