Training network in drug discovery targeting TRIM Ubiquitin ligases in disease

Project Information

TRIM-NET

Grant agreement ID: 813599

DOI

10.3030/813599

Project closed

EC signature date 30 August 2018

Start date 1 January 2019

End date 30 June 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 203 448,48

EU contribution

€ 3 203 448,48

Coordinated by

UNIVERSITA DEGLI STUDI DI TRIESTE
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (3)

TRIM-NET Closure meeting

Organisation of the Closure Meeting with B2.

Summer school

Summer/Winter School

Advertise positions for recruitment

Advertisement of the open call for PhD student positions available within the TRIM-NET network.

Websites, patent fillings, videos etc. (1)

TRIM-NET website

Creation of the TRIM-NET website together with B9 (WP3)

Publications

Peer reviewed articles (16)

TRIM25 targets p300 for degradation

Author(s): Seham Elabd, Eleonora Pauletto, Valeria Solozobova, Nils Eickhoff, Nuno Padrao, Wilbert Zwart, Christine Blattner
Published in: Life Science Alliance, 2023, ISSN 2575-1077
Publisher: Alliance of EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press
DOI: 10.26508/lsa.202301980

MuRF1/TRIM63, Master Regulator of Muscle Mass

Author(s): Dulce Peris-Moreno, Daniel Taillandier, Cécile Polge
Published in: International Journal of Molecular Sciences, Issue 21/18, 2020, Page(s) 6663, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21186663

Ubiquitination, Biotech Startups, and the Future of TRIM Family Proteins: A TRIM-Endous Opportunity.

Author(s): Utsa Bhaduri; Utsa Bhaduri; Giuseppe Merla; Giuseppe Merla
Published in: Cells, Vol 10, Iss 1015, p 1015 (2021), Issue 1, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10051015

TRIMming Down Hormone-Driven Cancers: The Biological Impact of TRIM Proteins on Tumor Development, Progression and Prognostication

Author(s): Eleonora Pauletto; Nils Eickhoff; Nuno Padrão; Christine Blattner; Wilbert Zwart
Published in: Cells, Vol 10, Iss 1517, p 1517 (2021), Issue 2, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.5445/ir/1000135752

To Ubiquitinate or Not to Ubiquitinate: TRIM17 in Cell Life and Death

Author(s): Meenakshi Basu-Shrivastava, Alina Kozoriz, Solange Desagher, Iréna Lassot
Published in: Cells, Issue 10/5, 2021, Page(s) 1235, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10051235

UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin.

Author(s): Dulce Peris-Moreno; Mélodie Malige; Agnès Claustre; Andrea Armani; Cécile Coudy-Gandilhon; Christiane Deval; Daniel Béchet; Pierre Fafournoux; Marco Sandri; Lydie Combaret; Daniel Taillandier; Cécile Polge
Published in: Cells, Vol 10, Iss 1974, p 1974 (2021), Issue 2, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10081974

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase

Author(s): Chen Z, Zhang J, Murillo-de-Ozores AR, Castañeda-Bueno M, D'Amico F, Heilig R, Manning CE, Sorrell FJ, D'Angiolella V, Fischer R, Mulder MPC, Gamba G, Alessi DR , Bullock AN.
Published in: Biochemical Journal, 2022, Page(s) Mar 18;479(5):661-675, ISSN 1470-8728
Publisher: Portland Press
DOI: 10.1042/bcj20220019

Rise of TRIM8: A Molecule of Duality

Author(s): Utsa Bhaduri, Giuseppe Merla
Published in: Molecular Therapy - Nucleic Acids, Issue 22, 2020, Page(s) 434-444, ISSN 2162-2531
Publisher: Nature Publishing Group
DOI: 10.1016/j.omtn.2020.08.034

Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class

Author(s): Francesca D'Amico, Rishov Mukhopadhyay, Huib Ovaa, Monique P. C. Mulder
Published in: ChemBioChem, Issue 22/12, 2021, Page(s) 2011-2031, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000787

TRIM32 and Malin in Neurological and Neuromuscular Rare Diseases

Author(s): Lorena Kumarasinghe, Lu Xiong, Maria Adelaida Garcia-Gimeno, Elisa Lazzari, Pascual Sanz, Germana Meroni
Published in: Cells, Issue 10/4, 2021, Page(s) 820, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10040820

A high-field cellular DNP-supported solid-state NMR approach to study proteins with sub-cellular specificity

Author(s): David Beriashvili, Ru Yao, Francesca D'Amico, Michaela Krafčíková, Andrei Gurinov, Adil Safeer, Xinyi Cai, Monique P C Mulder, Yangping Liu, Gert E Folkers, Marc Baldus
Published in: Chemical Science, 2023, Page(s) 14(36):9892-9899, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sc02117c

Ubiquitin Ligases at the Heart of Skeletal Muscle Atrophy Control

Author(s): Dulce Peris-Moreno, Laura Cussonneau, Lydie Combaret, Cécile Polge, Daniel Taillandier
Published in: Molecules, Issue 26/2, 2021, Page(s) 407, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26020407

Regulation of p53 by E3s

Author(s): Mengwu Pan, Christine Blattner
Published in: Cancers, Issue 13/4, 2021, Page(s) 745, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13040745

SUMO protease SENP6 protects the nucleus from hyperSUMOylation-induced laminopathy-like alterations

Author(s): Liczmanska M, Tatham MH, Mojsa B, Eugui-Anta A, Rojas-Fernandez A, Ibrahim AFM, Hay RT.
Published in: Cell Reports, 2023, Page(s) Aug 8;42(8):112960, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112960

Microtubular TRIM36 E3 Ubiquitin Ligase in Embryonic Development and Spermatogenesis

Author(s): Martina Mascaro; Inês Lages; Germana Meroni
Published in: Cells, Vol 11, Iss 246, p 246 (2022), Issue 2, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11020246

P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora disease

Author(s): Kumarasinghe, Lorena; García-Gimeno, María Adelaida; Ramirez, J.; Mayor, U.; Zugaza, J. L.; Sanz, Pascual
Published in: Neurobiology of Disease, 2023, Page(s) Feb;177:105998, ISSN 1095-953X
Publisher: Elsevier
DOI: 10.1016/j.nbd.2023.105998