Project description
New computational tools to leverage shockwave-induced bubbles and their effects on soft matter
Ultrasound cavitation, the generation of tiny cavities or bubbles induced by ultrasonic shockwaves, is used in several medical applications. However, the processes of interaction among the shockwaves, bubbles and soft matter are not well understood and can be harmful. With the support of the Marie Skłodowska-Curie Actions programme, the UCOM project will create a training network to explore these processes on the microscale and macroscale using a combined experimental and computational approach. The experimentally validated computational tools will pave the way for innovations with applications not only to medicine but also to surface cleaning, food processing and more.
Objective
The pressures and temperatures developing during the interactions of shockwaves with cavitation bubbles and soft matter induce complex phenomena, both at physical and biochemical levels. These have a non- exhaustive range of relevant applications including ultrasound-based therapies, surface cleaning and food processing. Our aim is to explore these processes both in micro and macroscales using experiments and to develop new computational capabilities for their simulations. Measurements will include temperature/ species forming in collapsing bubbles, identifying chemical reactions and possible tissue interaction, such as protein denaturation and agglomeration; tissue cavitation threshold and its control using nanoparticles, allowing development of new cavitation-mimicking-tissue materials extrapolating to actual tissue properties that will be used for in-vitro testing of equipment with minimum collateral damages. Computations will be based on advanced multi-resolution methods coupling fluid flow, chemical reactions and deforming material mechanics solvers, with physically consistent thermodynamic closure models for the involved materials; pressure wave propagation, bubble nucleation and material damage effects will link microscale phenomena to macroscale. Uncertainty quantification techniques will link computations with experimental data. UCOM builds upon the strong foundations of the PIs and their teams in training researchers in computational and experimental methods on cavitation and their strong record to successfully integrate research and technical applications. The final goal of the research and training program is to explore the enormous potential of the new and experimentally validated computational tools to guide breakthrough innovations and high-impact, high-tech technologies ranging across different sectors that all eventually enhance their careers and will be serving the well-being.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences condensed matter physics soft matter physics
- natural sciences biological sciences biochemistry biomolecules proteins
- engineering and technology nanotechnology nano-materials
- natural sciences computer and information sciences computational science multiphysics
- natural sciences physical sciences acoustics ultrasound
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-ITN-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
EC1V 0HB LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.