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Developing novel tools and technologies to assess the safety and efficacy of cell-based regenerative medicine therapies, focusing on kidney disease

Deliverables

RenalToolBox Workshop 3

RenalToolBox Workshop 3

Project Manager recruited

Project Manager recruited

ESRs recruited

ESRs recruited

Advertisement of ESR positions

ESR positions advertised

RenalToolBox Workshop 1

RenalToolBox Workshop 1

RenalToolBox Workshop 2

RenalToolBox Workshop 2

RenalToolBox website

Launch of RenalToolBox website containing public information area, updated throughout the project.

RenalToolBox website set up

RenalToolBox website set up

Communication/dissemination plan

Communication/dissemination plan

Press release

Press release informing public of RenalToolBox network and its objectives

Supervisory board

Supervisory board of the network established.

Publications

Firefly luciferase offers superior performance to AkaLuc for tracking the fate of administered cell therapies

Author(s): Francesco Amadeo; Francesco Amadeo; Antonius Plagge; Anitta Chacko; Anitta Chacko; Bettina Wilm; Vivien Hanson; Neill J. Liptrott; Patricia Murray; Arthur Taylor
Published in: European Journal of Nuclear Medicine and Molecular Imaging, 49, 2021, Page(s) 796-808, ISSN 1619-7089
Publisher: Springer
DOI: 10.1007/s00259-021-05439-4

Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis

Author(s): Willeke de Haan, Wouter Dheedene, Katerina Apelt, Sofiane Décombas-Deschamps, Stefan Vinckier, Stefaan Verhulst, Andrea Conidi, Thomas Deffieux, Michael W Staring, Petra Vandervoort, Ellen Caluwé, Marleen Lox, Inge Mannaerts, Tsuyoshi Takagi, Joris Jaekers, Geert Berx, Jody Haigh, Baki Topal, An Zwijsen, Yujiro Higashi, Leo A van Grunsven, Wilfred F J van IJcken, Eskeatnaf Mulugeta, Mickael Tant
Published in: Cardiovascular Research, 118(5), 2022, Page(s) 1262–1275, ISSN 1755-3245
Publisher: Oxford Academic
DOI: 10.1093/cvr/cvab148

Protein-Bound Uremic Toxins Induce Reactive Oxygen Species-Dependent and Inflammasome-Mediated IL-1β Production in Kidney Proximal Tubule Cells

Author(s): Mihajlovic, Milos; Krebber, Merle; Yang,Yi; Ahmed, Sabbir; Lozovanu, Valeria; Andreeva, Daria; Verhaar, Marianne; Masereeuw, Rosalinde
Published in: Biomedicines, 9(10), 2021, Page(s) 1326, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines9101326

An overview of non-invasive methods for transcutaneous measurements of glomerular filtration

Author(s): Yusuf, Mohammed M; Picascia,Tiziana; Vajpayee,Srishti; Perciaccante,Rossana; Gretz, Norbert
Published in: Journal of Experimental Nephrology, 2, 2021, Page(s) 7-14, ISSN 2767-3383
Publisher: Probiologists
DOI: 10.46439/nephrology.2.008

Diabetic proximal tubulopathy: Can we mimic the disease for in vitro screening of SGLT inhibitors?

Author(s): JoãoFaria, Karin G.F.Gerritsen, Tri Q.Nguyen, Silvia M.Mihaila, RosalindeMasereeuw
Published in: European Journal of Pharmacology, 908, 2021, Page(s) 174378, ISSN 0014-2999
Publisher: Elsevier BV
DOI: 10.1016/j.ejphar.2021.174378

Imaging the Renal Microcirculation in Cell Therapy.

Author(s): Katerina Apelt; Roel Bijkerk; Franck Lebrin; Franck Lebrin; Ton J. Rabelink
Published in: Cells, 10(5), 2021, Page(s) 1087, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10051087

The Influence of OAT1 Density and Functionality on Indoxyl Sulfate Transport in the Human Proximal Tubule: An Integrated Computational and In Vitro Study

Author(s): King, Jasia; Mihaila, Silvia; Ahmed, Sabbir; Truckenmüller, Roman; Giselbrecht, Stefan; Masereeuw, Rosalinde; Carlier, Aurélie
Published in: Toxins, 13(10), 2021, Page(s) 674, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins13100674

Mesenchymal stromal cells: what have we learned so far about their therapeutic potential and mechanisms of action?

Author(s): Francesco Amadeo; Katherine Trivino Cepeda; James Littlewood; Bettina Wilm; Arthur Taylor; Patricia Murray
Published in: Emerging Topics in Life Sciences, 5(4), 2021, Page(s) 549-562, ISSN 2397-8562
Publisher: Portland Press
DOI: 10.1042/etls20210013

Application of ethyl cinnamate based optical tissue clearing and expansion microscopy combined with retrograde perfusion for 3D lung imaging

Author(s): Quanchao Sun, Tiziana Picascia, Arif ul Maula Khan, Cinzia Brenna, Vincent Heuveline, Anja Schmaus, Jonathan P. Sleeman, Norbert Gretz
Published in: Experimental Lung Research, 2020, Page(s) 1-16, ISSN 0190-2148
Publisher: Taylor & Francis
DOI: 10.1080/01902148.2020.1829183

Surface Marker Expression in Small and Medium/Large Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Naive or Apoptotic Condition Using Orthogonal Techniques

Author(s): Skovronova Renata; Grange Cristina; Dimuccio Veronica; Deregibus Maria Chiara; Camussi Giovanni; Bussolati Benedetta
Published in: Cells, 10(11), 2021, Page(s) 2948, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10112948

Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration

Author(s): Grange, Skovronova, Marabese, Bussolati
Published in: Cells, 8/10, 2019, Page(s) 1240, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells8101240

Kidney-based in vitro models for drug-induced toxicity testing

Author(s): João Faria, Sabbir Ahmed, Karin G. F. Gerritsen, Silvia M. Mihaila, Rosalinde Masereeuw
Published in: Archives of Toxicology, 93/12, 2019, Page(s) 3397-3418, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-019-02598-0

Recent advances in understanding mesenchymal stromal cells

Author(s): Erika Rendra, Eleonora Scaccia, Karen Bieback
Published in: F1000Research, 9, 2020, Page(s) 156, ISSN 2046-1402
Publisher: F1000 Research Ltd.
DOI: 10.12688/f1000research.21862.1

Extracellular Vesicles Derived from Induced Pluripotent Stem Cells Promote Renoprotection in Acute Kidney Injury Model

Author(s): Federica Collino, Jarlene A. Lopes, Marta Tapparo, Giovane G. Tortelote, Taís H. Kasai-Brunswick, Gustavo M.C. Lopes, Douglas B. Almeida, Renata Skovronova, Camila H. C. Wendt, Kildare R. de Miranda, Benedetta Bussolati, Adalberto Vieyra, Rafael Soares Lindoso
Published in: Cells, 9/2, 2020, Page(s) 453, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9020453

Extracellular Vesicles, Apoptotic Bodies and Mitochondria: Stem Cell Bioproducts for Organ Regeneration

Author(s): Natalia Gebara, Andrea Rossi, Renata Skovronova, Justine Mariam Aziz, Amish Asthana, Benedetta Bussolati
Published in: Current Transplantation Reports, 7/2, 2020, Page(s) 105-113, ISSN 2196-3029
Publisher: Springer
DOI: 10.1007/s40472-020-00282-2

When Origin Matters: Properties of Mesenchymal Stromal Cells From Different Sources for Clinical Translation in Kidney Disease

Author(s): Sandra Calcat-i-Cervera, Clara Sanz-Nogués and Timothy O'Brien
Published in: Frontiers in Medicine, 8, 2021, ISSN 2296-858X
Publisher: Frontiers
DOI: 10.3389/fmed.2021.728496

Drugs Commonly Applied to Kidney Patients May Compromise Renal Tubular Uremic Toxins Excretion

Author(s): Silvia M. Mihaila, João Faria, Maurice F. J. Stefens, Dimitrios Stamatialis, Marianne C. Verhaar, Karin G. F. Gerritsen, Rosalinde Masereeuw
Published in: Toxins, 12/6, 2020, Page(s) 391, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12060391

New technical approaches for 3D morphological imaging and quantification of measurements

Author(s): Cinzia Brenna, Arif ul Maula Khan, Tiziana Picascia, Quanchao Sun, Vincent Heuveline, Norbert Gretz
Published in: The Anatomical Record, 303/10, 2020, Page(s) 2702-2715, ISSN 1932-8486
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ar.24463