A multidisciplinary approach towards sustainable improvement in rare diseases care uniting Europe's top class vascular research to find new treatment strategies for vascular anomalies

Project Information

V.A. Cure

Grant agreement ID: 814316

DOI 10.3030/814316

Project closed

EC signature date 13 September 2018

Start date 1 March 2019

End date 28 February 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 792 135,60

EU contribution € 3 792 135,60

Coordinated by

DE DUVE INSTITUTE AISBL
Belgium

Deliverables

Websites, patent fillings, videos etc. (5)

Scientific blog active
Scientific presentations and publications

Scientific presentations and publications Per ESR 3 or more presentations at nationalinternational scientific conferences and 2 or more publications published or accepted in peerreviewed journals in peerreviewed journals

V.A. Cure elevator pitches online
Website online
V.A. Cure screencast online

Publications

Peer reviewed articles (9)

Impaired retinoic acid signaling in cerebral cavernous malformations

Author(s): Grdseloff N, Boulday G, Rödel CJ, Otten C, Vannier DR, Cardoso C, Faurobert E, Dogra D, Tournier-Lasserve E, Abdelilah-Seyfried S
Published in: Sci. Rep., Issue Apr 5;13(1):5572, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-31905-0

Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional Extensions. 2023 . doi:. Epub ahead of print. PMID: 36806740.

Author(s): Nawaz M, Heydarkhan-Hagvall S, Tangruksa B, González-King Garibotti H, Jing Y, Maugeri M, Kohl F, Hultin L, Reyahi A, Camponeschi A, Kull B, Christoffersson J, Grimsholm O, Jennbacken K, Sundqvist M, Wiseman J, Bidar AW, Lindfors L, Synnergren J, Valadi H.
Published in: Adv Sci (Weinh)., Issue Feb 19:e2206187, 2023, ISSN 2198-3844
Publisher: Wiley-VCH
DOI: 10.1002/advs.202206187

Mechanosensitive Notch-Dll4 and Klf2-Wnt9 signaling pathways intersect in guiding valvulogenesis in zebrafish

Author(s): Alessio Paolini, Federica Fontana, Van-Cuong Pham, Claudia Jasmin Rödel, SalimAbdelilah-Seyfried
Published in: Cell Reports, Issue 5, 37(1), 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109782

Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10

Author(s): Claire Bouvard, Ly Tu, Martina Rossi, Agnès Desroches-Castan, Nihel Berrebeh, Elise Helfer, Caroline Roelants, Hequn Liu, Marie Ouarné, Nicolas Chaumontel, Christine Mallet, Christophe Battail, Andreas Bikfalvi, Marc Humbert, Laurent Savale, Thomas Daubon, Pascale Perret, Emmanuelle Tillet, Christophe Guignabert, Sabine Bailly
Published in: Cardiovascular Research, Issue 4 June 2021, 2021, ISSN 1755-3245
Publisher: Oxford University Press
DOI: 10.1093/cvr/cvab187

Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation.

Author(s): Milena Petkova, Marle Kraft, Simon Stritt, Ines Martinez-Corral, Henrik Ortsäter, Michael Vanlandewijck, Bojana Jakic, Eulalia Baselga, Sandra D Castillo, Mariona Graupera, Christer Betsholtz, Taija Mäkinen
Published in: J Exp Med., Issue Apr 3;220(4):e20220741, 2023, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20220741

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth.

Author(s): Ong, Y.T., Andrade, J., Armbruster, M., Shi, C., Castro, M., Costa, A.S.H., Sugino, T., Eelen, G., Zimmermann, B., Wilhelm, K., Lim, J., Watanabe, S., Guenther, S., Schneider, A., Zanconato, F., Kaulich, M., Pan, D., Braun, T., Gerhardt, H., Efeyan, A., Carmeliet, P., Piccolo, S., Grosso, A.R. and Potente, M.
Published in: Nat. Metab., Issue 4, 2022, Page(s) 672–682, ISSN 2522-5812
Publisher: Springer Nature
DOI: 10.1038/s42255-022-00584-y

Universal toxin-based selection for precise genome engineering in human cells

Author(s): Li, S., Akrap, N., Cerboni, S. et al.
Published in: Nature Communications, Issue 12, 497 (2021), 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20810-z

Warning regarding hematological toxicity of tamoxifen activated CreERT2 in young Rosa26CreERT2 mice.

Author(s): Rossi M, Salomon A, Chaumontel N, Molet J, Bailly S, Tillet E, Bouvard C.
Published in: Sci Rep., Issue Apr 12;13(1):5976., 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-32633-1

The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice. 2021 . doi: 10.1158/0008-5472.CAN-19-1904. Epub 2020 Oct 9. PMID: 33037065.

Author(s): Kapiainen E, Kihlström MK, Pietilä R, Kaakinen M, Ronkainen VP, Tu H, Heikkinen A, Devarajan R, Miinalainen I, Laitakari A, Ansarizadeh M, Zhang Q, Wei GH, Ruddock L, Pihlajaniemi T, Elamaa H, Eklund L
Published in: Cancer Res., Issue Jan 1;81(1), 2021, Page(s) 129-143, ISSN 1538-7445
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-1904