Integrated IMMUnoprofiling of large adaptive CANcer patients cohorts

Project Information

IMMUcan

Grant agreement ID: 821558

DOI

10.3030/821558

Project closed

EC signature date 23 April 2019

Start date 1 March 2019

End date 30 June 2026

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 37 187 251,00

EU contribution

€ 17 830 000,00

Coordinated by

ORGANISATION EUROPEENNE POUR LA RECHERCHE ET LE TRAITEMENT DU CANCER AISBL
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (3)

Independent boards (EAB and SAB) up and constituted

Report on the composition of these boards.

Policy for third party access and use of project results

On month 1, it will be an agreement on the key principles regarding 3rd party access allowing to discuss contract with non-EORTC groups. The full policy will be available by month 6.

Leaflet in lay language

Leaflet explaining the project in lay language.

Other (1)

First newsletter circulated

First newsletter

Publications

Conference proceedings (10)

Abstract 176P Multiplex-immunoflourescence spatial patterns to predict triple-negative breast cancer molecular subtypes in the IMMUcan study

Author(s): A. Joaquin Garcia, J. Krawczyk, M. Rediti, K. Gogolewski, M. Możejko, S. Tissot, S. Rusakiewicz, L. Despland, M. Morfouace, R. Liechti, F. Marzetta, X. Wang, D. Vincent, J-C. Goeminne, J. Oliveira, H.S. Hong, M. Cesaroni, C. Sotiriou, E. Szczurek, L. Buisseret
Published in: Immuno-Oncology and Technology, 2023
Publisher: Elsevier
DOI: 10.1016/j.iotech.2023.100635

Abstract 179P Integrating multiplex immunofluorescence with gene expression data in the IMMUcan HER2-positive breast cancer cohort

Author(s): M. Rediti, A. Joaquin Garcia, S. Tissot, S. Rusakiewicz, L. Despland, M. Morfouace, R. Liechti, F. Marzetta, J. Oliveira, J-C. Goeminne, A. Capela Marques, L. Greillier, X. Wang, D. Vincent, H.S. Hong, M. Cesaroni, C. Sotiriou, L. Buisseret
Published in: Immuno-Oncology and Technology, 2023
Publisher: Elsevier
DOI: 10.1016/j.iotech.2023.100638

Abstract 186P Post-anti-PD1 tumor characterization of HPV-negative R/M SCCHN: An EORTC IMMUcan sub-project

Author(s): A. Van Der Elst, D. Herrero Saboya, L. Michon, M. Morfouace, R. Liechti, D. Schulz, P. Devanand, R. Galot, A. Essabar, V. Pancaldi, J. Merlevede, H.S. Hong, L. Martignetti, C
Published in: Immuno-Oncology and Technology, 2023
Publisher: Elsevier
DOI: 10.1016/j.iotech.2023.100645

Abstract 199P Scalable multiplexed image analysis across cancer types as part of the IMMUcan consortium

Author(s): N. Eling, J. Dorier, S. Rusakiewicz, S. Tissot, P. Devanand, M. Daniel, S. Déglise, B. Palau Fernandez, J. Windhager, M. Możejko, K. Gogolewski, J. Krawczyk, A. Essabbar, V. Pancaldi, E. Szczurek, M. Morfouace, H.S. Hong, R. Liechti, B. Bodenmiller, D. Schulz
Published in: Immuno-Oncology and Technology, 2023
Publisher: Elsevier
DOI: 10.1016/j.iotech.2023.100675

Abstract 195P IMMUcan: Toward a better understanding of the tumor microenvironment to inform precision oncology approaches

Author(s): M. Morfouace, L. Buisseret, B. Besse, J-P. Machiels, C. Sotiriou, M-S. Robert, D. Schaer, S. Rusakiewicz, D. Schulz, B. Fournier, H.S. Hong, R. Liechti
Published in: Immuno-Oncology and Technology, 2023
Publisher: Elsevier
DOI: 10.1016/j.iotech.2023.100654

Abstract 202P Discovery of immunological cellular neighborhoods from protein markers in spatial tumor data

Author(s): M. Możejko, K. Gogolewski, D. Schulz, N. Eling, J. Krawczyk, A. Możwiłło, M. Daniel, E. Staub, M. Mourface, H.S. Hong, B. Bodenmiller, E. Szczurek
Published in: Immuno-Oncology and Technology, 2023
Publisher: Elsevier
DOI: 10.1016/j.iotech.2023.100678

Abstract 2266P IMMUcan consortium: Focus on the first results of the non-small cell lung cancer (NSCLC) cohort

Author(s): M. Morfouace, D. Schulz, N. Eling, F. Marzetta, C. Loizides, S. Rusakiewicz, R. Liechti, H.S. Hong, M-S. Robert, P. Bironzo, T. Cufer, K. Oselin, N. Cloarec, J. Oliveira, B. Bodenmiller, B. Besse,
Published in: Annals of Oncology, 2023
Publisher: Elsevier
DOI: 10.1016/j.annonc.2023.09.1294

Abstract 4522: Pathologic complete response rate across triple negative breast cancer subtypes in the IMMUcan study

Author(s): Andrea Joaquin Garcia; Mattia Rediti; Abdelkader Benyagoub; Stéphanie Tissot; Sylvie Rusakiewicz; Robin Liechti; Flavia Marzetta; Nicolas Penel; Julio Oliveira; Jean-Charles Goeminne; Pierre Fournel; Andreia Capela; Xiaoxiao Wang; Delphine Vincent; Françoise Rothe; Marie Morfouace; Henoch Hong; Donald Jackson; Christos Sotiriou; Laurence Buisseret
Published in: Immuno-Oncology and Technology, 2023
Publisher: Elsevier
DOI: 10.1158/1538-7445.am2023-4522

Abstract 2274P: Deep learning-based prediction of pathologic complete response to neoadjuvant therapy in breast cancer using H&E images and RNA-Seq in the IMMUcan study

Author(s): C. Esposito, A. Joaquin Garcia, M. Rediti, N. Penel, J. Oliveira, J-C. Goeminne, P. Fournel, A. Capela Marques, M. Morfouace, L. Buisseret, H.S. Hong, C. Maussion
Published in: Annals of Oncology, 2023
Publisher: Elsevier
DOI: 10.1016/j.annonc.2023.09.1302

Abstract 1P Integrated data analysis within IMMUcan identifies prognostic features of early NSCLC

Author(s): D. Schulz, M. Morfouace, N. Eling, M. Daniel, S. Déglise, B. Palau Fernandez, J. Windhager, S. Rusakiewicz, S. Tissot, T. Trefzer, J. Merlevede, F. Marzetta, R. Liechti, H.S. Hong, T. Cufer, P. Bironzo, A-M.C. Dingemans, B. Besse, B. Bodenmiller
Published in: Immuno-Oncology and Technology, 2023
Publisher: Elsevier
DOI: 10.1016/j.iotech.2023.100473

Peer reviewed articles (8)

Genomic and Immune Landscape of Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck Progressing on Anti–PD-1 Treatment

Author(s): Athénaïs van der Elst, Daniel Herrero-Saboya, Lucas Michon, Marie Morfouace, Robin Liechti, Preethi Devanand, Daniel Schulz, Maya Persoons, Sylvie Rusakiewicz, Nils Eling, Paul-Antoine Nicolas, Marie-Sophie Robert, Stéphanie R. Tissot, Michelle Daniel, Bernd Bodenmiller, Henoch S. Hong, Rachel Galot, Paolo Bossi, Julio Oliveira, Florian Estrade, Caroline Even, Sophie Lucas, Pierre Saintigny, Lo
Published in: Cancer Immunology Research, Issue 14, 2026, Page(s) 608-624, ISSN 2326-6066
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-25-0979

Yes, IMMUcan! Unraveling the human tumor microenvironment

Author(s): Henoch Hong, Robin Liechti, Marie Morfouace
Published in: Immuno-Oncology Insights, Issue 2021; 2(5),, 2021, Page(s) 301–309, ISSN 2059-7800
Publisher: BioInsights Publishing Ltd
DOI: 10.18609/ioi.2021.038

CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy.

Author(s): Franken A, Bila M, Mechels A, Kint S, Van Dessel J, Pomella V, Vanuytven S, Philips G, Bricard O, Xiong J, Boeckx B, Hatse S, Van Brussel T, Schepers R, Van Aerde C, Geurs S, Vandecaveye V, Hauben E, Vander Poorten V, Verbandt S, Vandereyken K, Qian J, Tejpar S, Voet T, Clement PM, Lambrechts D.
Published in: Immunity, 2024, ISSN 1097-4180
Publisher: Elsevier
DOI: 10.1016/j.immuni.2024.02.007

Multi-modal image analysis for large-scale cancer tissue studies within IMMUcan

Author(s): Nils Eling, Julien Dorier, Sylvie Rusakiewicz, Robin Liechti, Preethi Devanand, Michelle Daniel, Jonas Windhager, Bruno Palau Fernandez, Sophie Déglise, Lucie Despland, Abdelkader Benyagoub, Marcin Możejko, Dawid Uchal, Ewa Szczurek, Alexander Loboda, Daaf Sandkuijl, Nikesh Parsotam, Henoch S. Hong, Marie Morfouace, Nicolas Guex, George Coukos, Bernd Bodenmiller, Stephanie Tissot, Daniel Schulz
Published in: Cell Reports Methods, Issue 5, 2025, Page(s) 101170, ISSN 2667-2375
Publisher: Elsevier BV
DOI: 10.1016/j.crmeth.2025.101170

Abstract 1177: Tumor-associated macrophages and clinical outcomes to immunotherapy

Author(s): Henoch S. Hong, Marzena Mura, Jing Yang, Aslihan Gerhold-Ay, Thomas Mrowiec, Daniel Schulz, Bernd Bodenmiller, Robin Liechti, Marie Morfouace, Parantu Shah, Alex Rolfe
Published in: Cancer Research, Issue 85, 2025, Page(s) 1177-1177, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/1538-7445.am2025-1177

Meta-analysis of human cancer single cell RNA-seq datasets using the IMMUcan database.

Author(s): Jordi Camps; Floriane Noël; Robin Liechti; Lucile Massenet-Regad; Sidwell Rigade; Lou Götz; Caroline Hoffmann; Elise Amblard; Melissa Saichi; Mahmoud M. Ibrahim; Jack Pollard; Jasna Medvedovic; Helge G. Roider; Vassili Soumelis
Published in: Cancer Research, 2023, ISSN 1538-7445
Publisher: AACR
DOI: 10.1158/0008-5472.can-22-0074

333P A multi-omics analysis of advanced triple-negative breast cancer (TNBC) identifies predictors to chemo-immunotherapy and on-treatment dynamics

Author(s): E. Agostinetto, N. Van Renne, A. Joaquín García, M. Morfouace, M. Mozejko, Z. Denis, H.S. Hong, D. Venet, R. Liechti, S. Tissot, M. Rediti, X. Catteau, D. Schulz, D. Loirat, P. Aftimos, E. Romano, H. Wildiers, E. Szczurek, C. Sotiriou, L. Buisseret
Published in: Immuno-Oncology and Technology, Issue 28, 2026, Page(s) 101330, ISSN 2590-0188
Publisher: Elsevier BV
DOI: 10.1016/j.iotech.2025.101330

Molecular and Immune Landscape of Recurrent and/or Distant Metastatic Squamous Cell Carcinoma of the Head and Neck: An EORTC/IMMUCAN Project

Author(s): Athénaïs van der Elst, Daniel Herrero-Saboya, Lucas Michon, Marie Morfouace, Robin Liechti, Preethi Devanand, Daniel Schulz, Maya Persoons, Sylvie Rusakiewicz, Nils Eling, Paul-Antoine Nicolas, Marie-Sophie Robert, Stephanie Tissot, Sophie Déglise, Bruno Palau Fernandez, Bernd Bodenmiller, Henoch S. Hong, Rachel Galot, Paolo Bossi, Julio Oliveira, Marc Pracht, Caroline Even, Pierre Saintigny, C
Published in: Clinical Cancer Research, Issue 32, 2026, Page(s) 2732-2747, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-25-3377