Project description
Innovative carriers for more efficient photodynamic therapy
Photodynamic therapy (PDT) involves the use of a drug that is activated by light to kill cancer cells. The presence of oxygen is crucial for radical oxygen species generation, which causes the death of tumour cells. A major obstacle in PDT in cancer is the hypoxia in tumour tissue. Funded by the Marie Skłodowska-Curie Actions programme, the OXIGENATED project aims to develop haemoglobin drug delivery nanocarriers (HDDNs) for the simultaneous oxygen and photosensitiser delivery to tumour tissue for efficient PDT. The HDDNs will transport oxygen complexed to haemoglobin with the photosensitiser molecules entrapped in the core. The uptake of HDDNs by cells as well as their intracellular fate and toxicity will be tested in vitro. In vivo studies on mice will trace radiolabelled carriers using tomography.
Fields of science
- natural scienceschemical sciencesinorganic chemistryinorganic compounds
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health sciencesclinical medicineoncology
- engineering and technologyother engineering and technologiesmicrotechnologymolecular engineering
- natural sciencesbiological sciencesmolecular biology
Programme(s)
Coordinator
20009 San Sebastian
Spain
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Participants (3)
10117 Berlin
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51005 Tartu
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12489 Berlin
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partners (4)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
70919 970 Brasilia Df
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1650 San Martin Buenos Aires
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
8000 Bahia Blanca
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
10330 Bangkok
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