Skip to main content

Hemoglobin based Protein Nanocarriers for Tumour Oxygenation and a more effective Photodynamic Therapy

Objective

A major drawback of Photodynamic Therapy (PDT) and other therapies for cancer treatment is the limited oxygen content, hypoxia, in tumour tissue. In PDT a photosensitizing molecule is delivered to malignant tissue to generate radical oxygen species (ROS). The presence of oxygen is fundamental for ROS generation, ultimately causing the death of tumour cells.
This project aims to develop hemoglobin drug delivery nanocarriers in the nano and submicron range for simultaneous oxygen and photosensitizer delivery to tumour tissue for a more efficient Photodynamic Therapy.
Hemoglobin-based nanocarriers (HOBCs) will be prepared by co-precipitation of hemoglobin with carbonates and surface coating with bovine serum albumin. The carriers will transport oxygen complexed to hemoglobin while photosensitizer molecules will be entrapped in the core. Carriers will be modified with homing peptides to target them to cancer cells. In vitro studies will be conducted to study the uptake of HOBCs by cells, their intracellular fate, toxicity, and oxygen and photosensitizer delivery. In vivo fate of carriers will be studied in mice with radiolabeled carriers by Positron Emission Tomography and Single Emission Computer Tomography. The efficiency of the HOBCs for oxygen delivery and for PDT will be tested in vitro and in vivo in breast and skin cancer models.
A multidisciplinary team has been gathered with scientists at the forefront of Material Science, Self assembly, Physics, Chemistry, Imaging, Molecular Biology and Cancer Therapy from Germany, Estonia, Spain, Brazil, Argentina and Thailand. The participation of a SME will be fundamental for the future commercialization of project developments. OXIGENATED will actively work towards exchanging skills and knowledge through secondments of Early Stage and Experienced Researchers, and through networking and training activities. Seconded researchers will develop new scientific and complementary skills while exposed to new research environments.

Coordinator

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Net EU contribution
€ 547 400,00
Address
Paseo Miramon 182, Parque Tecnologico De San Sebastian Edificio Empresarial C
20009 San Sebastian
Spain

See on map

Region
Noreste País Vasco Gipuzkoa
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (3)

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
Net EU contribution
€ 239 200,00
Address
Chariteplatz 1
10117 Berlin

See on map

Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TARTU ULIKOOL
Estonia
Net EU contribution
€ 110 400,00
Address
Ulikooli 18
51005 Tartu

See on map

Region
Eesti Eesti Lõuna-Eesti
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Surflay Nanotec GmbH
Germany
Net EU contribution
€ 23 000,00
Address
Max Planck Strasse 3
12489 Berlin

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00

Partners (4)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

FUNDACAO UNIVERSIDADE DE BRASILIA
Brazil
Net EU contribution
€ 0,00
Address
Campus Universitario Darcy Ribeiro Faculdade De Tecnologie At 05 Bairro Asa Norte
70919 970 Brasilia Df

See on map

Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN
Argentina
Net EU contribution
€ 0,00
Address
Martin De Irigoyen 3100
1650 San Martin Buenos Aires

See on map

Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 124 384,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSIDAD NACIONAL DEL SUR
Argentina
Net EU contribution
€ 0,00
Address
Avenida Colon 80
8000 Bahia Blanca

See on map

Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 190 486,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

CHULALONGKORN UNIVERSITY
Thailand
Net EU contribution
€ 0,00
Address
Phyathai Road 254 Pathumwan
10330 Bangkok

See on map

Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 401 212,00