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Hemoglobin based Protein Nanocarriers for Tumour Oxygenation and a more effective Photodynamic Therapy

Project description

Innovative carriers for more efficient photodynamic therapy

Photodynamic therapy (PDT) involves the use of a drug that is activated by light to kill cancer cells. The presence of oxygen is crucial for radical oxygen species generation, which causes the death of tumour cells. A major obstacle in PDT in cancer is the hypoxia in tumour tissue. Funded by the Marie Skłodowska-Curie Actions programme, the OXIGENATED project aims to develop haemoglobin drug delivery nanocarriers (HDDNs) for the simultaneous oxygen and photosensitiser delivery to tumour tissue for efficient PDT. The HDDNs will transport oxygen complexed to haemoglobin with the photosensitiser molecules entrapped in the core. The uptake of HDDNs by cells as well as their intracellular fate and toxicity will be tested in vitro. In vivo studies on mice will trace radiolabelled carriers using tomography.

Coordinator

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Net EU contribution
€ 547 400,00
Address
Paseo Miramon 182, Parque Tecnologico De San Sebastian Edificio Empresarial C
20009 San Sebastian
Spain

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Region
Noreste País Vasco Gipuzkoa
Activity type
Research Organisations
Other funding
€ 547 400,00

Participants (3)

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
Net EU contribution
€ 239 200,00
Address
Chariteplatz 1
10117 Berlin

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 239 200,00
TARTU ULIKOOL
Estonia
Net EU contribution
€ 110 400,00
Address
Ulikooli 18
51005 Tartu

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Region
Eesti Eesti Lõuna-Eesti
Activity type
Higher or Secondary Education Establishments
Other funding
€ 110 400,00
Surflay Nanotec GmbH
Germany
Net EU contribution
€ 23 000,00
Address
Max Planck Strasse 3
12489 Berlin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 23 000,00

Partners (4)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

FUNDACAO UNIVERSIDADE DE BRASILIA
Brazil
Net EU contribution
€ 0,00
Address
Campus Universitario Darcy Ribeiro Faculdade De Tecnologie At 05 Bairro Asa Norte
70919 970 Brasilia Df

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN
Argentina
Net EU contribution
€ 0,00
Address
Martin De Irigoyen 3100
1650 San Martin Buenos Aires

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSIDAD NACIONAL DEL SUR
Argentina
Net EU contribution
€ 0,00
Address
Avenida Colon 80
8000 Bahia Blanca

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

CHULALONGKORN UNIVERSITY
Thailand
Net EU contribution
€ 0,00
Address
Phyathai Road 254 Pathumwan
10330 Bangkok

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00