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automatic detection and localization of High frequency Oscillation in Paediatric Epilepsy

Objective

In spite of the continuous development of new drugs that target molecular mechanisms responsible for generating epileptic seizures, approximately 25% of the patients with epilepsy are proven medically resistant. These patients should be evaluated for surgery to remove the area responsible for generating the attacks referred to as the epileptogenic zone (EZ). Surgical outcomes strongly depend on the accuracy of the recognition of the EZ, which is currently identified using a potential range of diagnostic tests. In such cases, long-term intracranial electroencephalogram (iEEG) monitoring is used to correctly characterise the seizures and establish the surgical approach. iEEG monitoring has however its limitations, which are mainly found in its invasiveness, cost and the limited spatial sampling - i.e. the chance to record activity propagated from other close areas and not originated where electrodes are placed. To date, this results in a significant number of patients continuing to experience postsurgical seizures.
During the last few years, high-frequency oscillations (HFOs above 80 Hz) have emerged as a new promising biomarker in pre-surgical diagnosis of epileptogenicity. Indeed, recent studies have shown that the resection of the tissue generating HFOs improves surgical outcome in patients with medically refractory epilepsy (MRE).
HOPE aims to facilitate the interaction between academic, clinical industrial partners to produce a step-change in our ability to detect and quantify HFOs using non-invasive investigations like EEG and MEG, tackling the existing limitations at computational, hardware and software level. As the HFOs are a paradigmatic case for signal detection in low signal/noise condition, the technology will also benefit research in neurofeedback and BCI recordings and allow is to develop and evaluate a neurofeedback platform for the self-modulation of HFOs, and it’s relevance to clinical management of MRE.

Field of science

  • /medical and health sciences/clinical medicine/surgery
  • /medical and health sciences/basic medicine/neurology/epilepsy
  • /natural sciences/computer and information sciences/software

Call for proposal

H2020-MSCA-RISE-2018
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

ASTON UNIVERSITY
Address
Aston Triangle
B4 7ET Birmingham
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 276 000

Participants (11)

STICHTING VUMC
Netherlands
EU contribution
€ 4 600
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 13 800
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece
EU contribution
€ 165 600
Address
Kedea Building, Tritis Septemvriou, Aristotle Univ Campus
54636 Thessaloniki
Activity type
Higher or Secondary Education Establishments
POLYTECHNEIO KRITIS
Greece
EU contribution
€ 73 600
Address
Building E4, Technical University Campus Counoupidiana
731 00 Chania
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
EU contribution
€ 128 800
Address
Via Cracovia 50
00133 Roma
Activity type
Higher or Secondary Education Establishments
AAI SCIENTIFIC CULTURAL SERVICES LIMITED
Cyprus
EU contribution
€ 193 200
Address
Avenue Arch Makariou Iii 33 Galaxias Centre 5Th Floor Office 501
1065 Lefkosia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BRAINSIGNS SRL
Italy
EU contribution
€ 110 400
Address
Lungotevere Michelangelo, 9
00192 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
G.TEC MEDICAL ENGINEERING GMBH
Austria
EU contribution
€ 105 800
Address
Sierningstrasse 14
4521 Schiedlberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITOYTO BIOIATPIKHE TEXNOLOGIAS
Greece
EU contribution
€ 59 800
Address
Mavropodia Platani Patras Science Park
26504 Patras
Activity type
Other
YORK INSTRUMENTS LTD
United Kingdom
EU contribution
€ 82 800
Address
The Biocentre Innovation Way, York Science Park
YO105NY York
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIRMINGHAM WOMENS AND CHILDRENS NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 0
Address
Steelhouse Lane
B4 6NH Birmingham
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)

Partners (1)

CHILDREN'S HOSPITAL CORPORATION
United States
Address
Longwood Avenue 300
02115 Boston
Activity type
Research Organisations