Objective In spite of the continuous development of new drugs that target molecular mechanisms responsible for generating epileptic seizures, approximately 25% of the patients with epilepsy are proven medically resistant. These patients should be evaluated for surgery to remove the area responsible for generating the attacks referred to as the epileptogenic zone (EZ). Surgical outcomes strongly depend on the accuracy of the recognition of the EZ, which is currently identified using a potential range of diagnostic tests. In such cases, long-term intracranial electroencephalogram (iEEG) monitoring is used to correctly characterise the seizures and establish the surgical approach. iEEG monitoring has however its limitations, which are mainly found in its invasiveness, cost and the limited spatial sampling - i.e. the chance to record activity propagated from other close areas and not originated where electrodes are placed. To date, this results in a significant number of patients continuing to experience postsurgical seizures. During the last few years, high-frequency oscillations (HFOs above 80 Hz) have emerged as a new promising biomarker in pre-surgical diagnosis of epileptogenicity. Indeed, recent studies have shown that the resection of the tissue generating HFOs improves surgical outcome in patients with medically refractory epilepsy (MRE).HOPE aims to facilitate the interaction between academic, clinical industrial partners to produce a step-change in our ability to detect and quantify HFOs using non-invasive investigations like EEG and MEG, tackling the existing limitations at computational, hardware and software level. As the HFOs are a paradigmatic case for signal detection in low signal/noise condition, the technology will also benefit research in neurofeedback and BCI recordings and allow is to develop and evaluate a neurofeedback platform for the self-modulation of HFOs, and it’s relevance to clinical management of MRE. Fields of science medical and health sciencesbasic medicineneurologyepilepsynatural sciencescomputer and information sciencessoftwaremedical and health sciencesclinical medicinesurgery Keywords epilepsy HFOs EEG MEG neuroimaging neuroscience seizure onset zone Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Topic(s) MSCA-RISE-2018 - Research and Innovation Staff Exchange Call for proposal H2020-MSCA-RISE-2018 See other projects for this call Funding Scheme MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinator ASTON UNIVERSITY Net EU contribution € 276 000,00 Address Aston triangle B4 7ET Birmingham United Kingdom See on map Region West Midlands (England) West Midlands Birmingham Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (11) Sort alphabetically Sort by Net EU contribution Expand all Collapse all STICHTING VUMC Netherlands Net EU contribution € 4 600,00 Address De boelelaan 1117 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAIR MEDISCH CENTRUM UTRECHT Netherlands Net EU contribution € 13 800,00 Address Heidelberglaan 100 3584 CX Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ARISTOTELIO PANEPISTIMIO THESSALONIKIS Greece Net EU contribution € 165 600,00 Address Kedea building, tritis septemvriou, aristotle university campus 546 36 Thessaloniki See on map Region Βόρεια Ελλάδα Κεντρική Μακεδονία Θεσσαλονίκη Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 POLYTECHNEIO KRITIS Greece Net EU contribution € 73 600,00 Address Building e4, technical university campus counoupidiana 731 00 Chania See on map Region Νησιά Αιγαίου Κρήτη Χανιά Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA Italy Net EU contribution € 128 800,00 Address Via cracovia 50 00133 Roma See on map Region Centro (IT) Lazio Roma Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 AAI SCIENTIFIC CULTURAL SERVICES LIMITED Cyprus Net EU contribution € 193 200,00 Address Avenue arch makariou iii 33 galaxias centre 5th floor office 501 1065 Lefkosia See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Κύπρος Κύπρος Κύπρος Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 BRAINSIGNS SRL Italy Net EU contribution € 110 400,00 Address Via tirso 14 00198 Roma See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Lazio Roma Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 G.TEC MEDICAL ENGINEERING GMBH Austria Net EU contribution € 105 800,00 Address Sierningstrasse 14 4521 Schiedlberg See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Westösterreich Oberösterreich Steyr-Kirchdorf Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INSTITOYTO BIOIATPIKHE TEXNOLOGIAS Greece Net EU contribution € 59 800,00 Address Mavropodia platani patras science park 26504 Patras See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Κεντρική Ελλάδα Δυτική Ελλάδα Αχαΐα Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 YORK INSTRUMENTS LTD United Kingdom Net EU contribution € 82 800,00 Address The biocentre innovation way, york science park YO105NY York See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Yorkshire and the Humber North Yorkshire York Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 BIRMINGHAM WOMENS AND CHILDRENS NHS FOUNDATION TRUST United Kingdom Net EU contribution € 0,00 Address Steelhouse lane B4 6NH Birmingham See on map Region West Midlands (England) West Midlands Birmingham Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. CHILDREN'S HOSPITAL CORPORATION United States Net EU contribution € 0,00 Address Longwood avenue 300 02115 Boston See on map Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
