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automatic detection and localization of High frequency Oscillation in Paediatric Epilepsy

Objective

In spite of the continuous development of new drugs that target molecular mechanisms responsible for generating epileptic seizures, approximately 25% of the patients with epilepsy are proven medically resistant. These patients should be evaluated for surgery to remove the area responsible for generating the attacks referred to as the epileptogenic zone (EZ). Surgical outcomes strongly depend on the accuracy of the recognition of the EZ, which is currently identified using a potential range of diagnostic tests. In such cases, long-term intracranial electroencephalogram (iEEG) monitoring is used to correctly characterise the seizures and establish the surgical approach. iEEG monitoring has however its limitations, which are mainly found in its invasiveness, cost and the limited spatial sampling - i.e. the chance to record activity propagated from other close areas and not originated where electrodes are placed. To date, this results in a significant number of patients continuing to experience postsurgical seizures.
During the last few years, high-frequency oscillations (HFOs above 80 Hz) have emerged as a new promising biomarker in pre-surgical diagnosis of epileptogenicity. Indeed, recent studies have shown that the resection of the tissue generating HFOs improves surgical outcome in patients with medically refractory epilepsy (MRE).
HOPE aims to facilitate the interaction between academic, clinical industrial partners to produce a step-change in our ability to detect and quantify HFOs using non-invasive investigations like EEG and MEG, tackling the existing limitations at computational, hardware and software level. As the HFOs are a paradigmatic case for signal detection in low signal/noise condition, the technology will also benefit research in neurofeedback and BCI recordings and allow is to develop and evaluate a neurofeedback platform for the self-modulation of HFOs, and it’s relevance to clinical management of MRE.

Coordinator

ASTON UNIVERSITY
Net EU contribution
€ 276 000,00
Address
Aston Triangle
B4 7ET Birmingham
United Kingdom

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Region
West Midlands (England) West Midlands Birmingham
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (11)

STICHTING VUMC
Netherlands
Net EU contribution
€ 4 600,00
Address
De Boelelaan 1117
1081 HV Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
Net EU contribution
€ 13 800,00
Address
Heidelberglaan 100
3584 CX Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece
Net EU contribution
€ 165 600,00
Address
Kedea Building, Tritis Septemvriou, Aristotle Univ Campus
54636 Thessaloniki

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Region
Θεσσαλονίκη Κεντρική Μακεδονία Βόρεια Ελλάδα
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
POLYTECHNEIO KRITIS
Greece
Net EU contribution
€ 73 600,00
Address
Building E4, Technical University Campus Counoupidiana
731 00 Chania

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Region
Χανιά Κρήτη Νησιά Αιγαίου
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
Net EU contribution
€ 128 800,00
Address
Via Cracovia 50
00133 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AAI SCIENTIFIC CULTURAL SERVICES LIMITED
Cyprus
Net EU contribution
€ 193 200,00
Address
Avenue Arch Makariou Iii 33 Galaxias Centre 5th Floor Office 501
1065 Lefkosia

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Κύπρος Κύπρος Κύπρος
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
BRAINSIGNS SRL
Italy
Net EU contribution
€ 110 400,00
Address
Lungotevere Michelangelo, 9
00192 Roma

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Centro (IT) Lazio Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
G.TEC MEDICAL ENGINEERING GMBH
Austria
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€ 105 800,00
Address
Sierningstrasse 14
4521 Schiedlberg

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Westösterreich Oberösterreich Steyr-Kirchdorf
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
INSTITOYTO BIOIATPIKHE TEXNOLOGIAS
Greece
Net EU contribution
€ 59 800,00
Address
Mavropodia Platani Patras Science Park
26504 Patras

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Αχαΐα Δυτική Ελλάδα Κεντρική Ελλάδα
Activity type
Other
Non-EU contribution
€ 0,00
YORK INSTRUMENTS LTD
United Kingdom
Net EU contribution
€ 82 800,00
Address
The Biocentre Innovation Way, York Science Park
YO105NY York

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Yorkshire and the Humber North Yorkshire York
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
BIRMINGHAM WOMENS AND CHILDRENS NHS FOUNDATION TRUST
United Kingdom
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€ 0,00
Address
Steelhouse Lane
B4 6NH Birmingham

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Region
West Midlands (England) West Midlands Birmingham
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

CHILDREN'S HOSPITAL CORPORATION
United States
Net EU contribution
€ 0,00
Non-EU contribution
€ 0,00