Project description
Novel biodegradable implants for older patients with osteochondral defects
The degeneration of cartilage in joints is associated with trauma or conditions such as osteoarthritis and rheumatic arthritis. To treat patients with these conditions, specific scaffolds are being developed for restorative procedures. The scaffolds should be biocompatible and biodegradable, able to control stem cell differentiation into osteoblasts via bioactive compounds, and they should also allow cell ingrowth from the adjacent tissues. Moreover, they should mimic the natural porous extracellular matrix of the tissue and form three-dimensional structures. Funded by the Marie Skłodowska-Curie Actions programme, the iP-OSTEO project aims to develop cell-based scaffolds for bone and cartilage repair in older patients with poor regenerative capacity. The proposed technology involves induced pluripotent stem cells with improved regeneration capacity and novel nanostructured scaffolds with a drug delivery system, stimulating cell regeneration.
Fields of science
Programme(s)
Coordinator
14220 Praha 4
Czechia
See on map
Participants (13)
11000 Praha
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
9026 Gyor
See on map
10827 Berlin
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
2970 Hoersholm
See on map
3500 Krems An Der Donau
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
WC1E 6BT London
See on map
47533 Kleve
See on map
30419 Hannover
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
0349 Oslo
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
80686 Munchen
See on map
4200-135 Porto
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
3723 MB Bilthoven
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
02-106 Warsaw
See on map