CORDIS - EU research results
CORDIS

Induced pluripotent stem cell seeded active osteochondral nanofibrous scaffolds

Project description

Novel biodegradable implants for older patients with osteochondral defects

The degeneration of cartilage in joints is associated with trauma or conditions such as osteoarthritis and rheumatic arthritis. To treat patients with these conditions, specific scaffolds are being developed for restorative procedures. The scaffolds should be biocompatible and biodegradable, able to control stem cell differentiation into osteoblasts via bioactive compounds, and they should also allow cell ingrowth from the adjacent tissues. Moreover, they should mimic the natural porous extracellular matrix of the tissue and form three-dimensional structures. Funded by the Marie Skłodowska-Curie Actions programme, the iP-OSTEO project aims to develop cell-based scaffolds for bone and cartilage repair in older patients with poor regenerative capacity. The proposed technology involves induced pluripotent stem cells with improved regeneration capacity and novel nanostructured scaffolds with a drug delivery system, stimulating cell regeneration.

Objective

iP-OSTEO project focuses on development of novel cell-based scaffolds for bone and cartilage repair in patients with poor regenerative capacity. We are proposing technology combining iPSCs with improved regeneration capacity combined with nanostructured scaffolds based on electrospun scaffolds and drug delivery system stimulating cell regeneration based on electrosprayed and spray-dried particles. The system will deliver novel treatment method for older patients, for which the current cellular and cell-free methods are ineffective.

iP-OSTEO will reach its goals by creating an international and interdisciplinary training program. 7 companies (SMEs) and 7 academic institutions across European Union will join there forces though dedicated secondments. The activities will involve networking, research/training, workshop and dissemination secondments. The project has in total 239 secondments involving exchange of Early-stage and Experienced researchers. The consortium is bonded by Dr. Eva Filova – young scientist with experience in bone and cartilage tissue engineering.

The iP-OSTEO project will help in better integration of academic and industrial stakeholders across Europe and help diseased people by providing novel therapeutic methods. Nevertheless, project has 169 ESR secondment months leading to training of new generation of scientists with international connection and knowledge of intrasectorial enviroment.

Coordinator

USTAV EXPERIMENTALNI MEDICINY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE
Net EU contribution
€ 257 600,00
Address
VIDENSKA 1083
14220 Praha 4
Czechia

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Region
Česko Praha Hlavní město Praha
Activity type
Research Organisations
Links
Total cost
€ 257 600,00

Participants (13)