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Gut OncoMicrobiome Signatures (GOMS) associated with cancer incidence, prognosis and prediction of treatment response.

Project description

Exploiting the gut microbiome for cancer diagnosis and treatment

Accumulating evidence underscores the role of the gut microbiome in health and disease, including cancer. The scope of the EU-funded ONCOBIOME project is to identify and functionally characterise the commensal bacteria of high clinical relevance. Using cohorts of more than 3 000 patients with cancer across 10 countries, project partners will identify microbiome signatures related to cancer occurrence, prognosis and response to therapy. They will also investigate the mechanistic interplay with the host metabolism, immunity and oncogenesis. Apart from fundamental knowledge, project results will lead to novel diagnostic and prognostic tests for cancer, as well as tailor-made pre- and pro-biotics.


Beyond the role the intestinal metagenome plays in regulating multiple physBeyond its role in regulating multiple physiological functions that impact health, the intestinal metagenome is implicated in cancer initiation, progression and responses to therapies, even for extraintestinal neoplasia. Hence, there is an urgent need to fully identify and functionally characterize minimalist commensal ecosystems relevant to cancer, with reliable and robust methods, to validate cancer-associated gut microbiome fingerprints of high clinical relevance, and to develop diagnosis tools that will become part of the oncological arsenal for the optimization and personalization of therapy. Based on retro-and pro-spective studies, with large discovery and validation cohorts enrolling >9,000 cancer patients across 10 countries, ancillary to ongoing innovative clinical trials or FDA/EMA approvals across 4 frequent cancer types, ONCOBIOME will pursue the following aims: 1/ identify and validate core or cancer-specific Gut OncoMicrobiome Signatures (GOMS) associated with cancer occurrence, prognosis, response to, or progression on, therapy (polychemotherapy, immune checkpoint inhibitors, dendritic cell vaccines) or adverse effects, 2/ decipher the functional relevance of these cancer-associated gut commensal ecosystems in the regulation of host metabolism, immunity and oncogenesis, 3/ integrate these GOMS with other oncology hallmarks (clinics, genomics, immunomics, metabolomics) 4/ design optimal companion tests, based on those integrated signatures to predict cancer occurrence and progression. With high carat interdisciplinary experts, ONCOBIOME expects to validate cancer or therapy-specific Gut OncoMicrobiome Signatures (GOMS) across breast, colorectal, melanoma and lung cancers adjusting for covariates, to unravel the mode of action of these GOMS in innovative platforms, thus lending support to the design of cancer preventive campaigns using well characterized pre-and pro-biotics.

Call for proposal


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Sub call



Net EU contribution
€ 2 359 201,00
Rue camille desmoulins 39
94805 Villejuif

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Ile-de-France Ile-de-France Val-de-Marne
Other funding
€ 0,00

Participants (22)