Project description
Lung cancer detection with a simple blood test
Lung cancer constitutes a leading cause of death worldwide with most patients being diagnosed at a late stage. Survival rates are higher and clinical outcome is better when the disease is detected early. The rationale behind the EU-funded Lung EpiCheck project is that a simple diagnostic test for high-risk patients would increase compliance and deliver long-term health benefits. To achieve this, the team has developed a simple blood test that detects circulating tumour DNA and identifies subtle disease-related changes in DNA methylation markers. The objectivity and sensitivity of the test render it a powerful tool in the diagnosis of lung cancer.
Objective
Nucleix has developed a highly innovative process for cancer diagnostics. The company plans to introduce Innovative Technique for Lung Cancer Diagnostics via identification of changes in DNA Methylation in Blood Samples. The company has already introduced successfully the Bladder EpiCheck and gained experience in the process of: clinical validation, regulatory approvals and commercialization of bladder cancer diagnostic of cancer via identification of changes in DNA Methylation. Nucleix’s current technology of lung cancer detection in blood samples – Lung EpiCheck - was developed using the same technology and team which has successfully developed Bladder EpiCheck.
Nucleix breakthrough innovations are in the area of cancer detection using a unique combination of a best-in-class biochemical tool, combined with advanced big-data bioinformatics analysis. Lung EpiCheck is a high-potential innovation idea and though having some risk in the process of market adaptation it creates a very high commercial opportunity for Nucleix for growth and a successful mature enterprise
At present, lung cancer is usually detected at late stages, where survival rates are very low – about 15%. The reason for this is that lung cancer patients are mostly asymptomatic in early stages. Detecting lung cancer in early stages significantly improves survival rates to 50% to 80%, thus a good tool for lung cancer detection has huge potential.
The current high clinical results of Lung EpiCheck and the meetings with European potential customers (such as leading medical centers and lab chains) shows that the project proposed methodology and the expected performance is very promising to potential customers and market leaders. These potential customers have also confirmed company’s assumption about pricing that provides proper value for money. Nucleix’s technology is expected to create a huge value proposition to patients, physicians and payers identified as the main stakeholders
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.2.3. - INDUSTRIAL LEADERSHIP - Innovation In SMEs
MAIN PROGRAMME
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H2020-EU.3. - PRIORITY 'Societal challenges
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H2020-EU.2.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
SME-2 - SME instrument phase 2
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-EIC-SMEInst-2018-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
7670203 REHOVOT
Israel
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.