Project description
Lung cancer detection with a simple blood test
Lung cancer constitutes a leading cause of death worldwide with most patients being diagnosed at a late stage. Survival rates are higher and clinical outcome is better when the disease is detected early. The rationale behind the EU-funded Lung EpiCheck project is that a simple diagnostic test for high-risk patients would increase compliance and deliver long-term health benefits. To achieve this, the team has developed a simple blood test that detects circulating tumour DNA and identifies subtle disease-related changes in DNA methylation markers. The objectivity and sensitivity of the test render it a powerful tool in the diagnosis of lung cancer.
Objective
Nucleix has developed a highly innovative process for cancer diagnostics. The company plans to introduce Innovative Technique for Lung Cancer Diagnostics via identification of changes in DNA Methylation in Blood Samples. The company has already introduced successfully the Bladder EpiCheck and gained experience in the process of: clinical validation, regulatory approvals and commercialization of bladder cancer diagnostic of cancer via identification of changes in DNA Methylation. Nucleix’s current technology of lung cancer detection in blood samples – Lung EpiCheck - was developed using the same technology and team which has successfully developed Bladder EpiCheck.
Nucleix breakthrough innovations are in the area of cancer detection using a unique combination of a best-in-class biochemical tool, combined with advanced big-data bioinformatics analysis. Lung EpiCheck is a high-potential innovation idea and though having some risk in the process of market adaptation it creates a very high commercial opportunity for Nucleix for growth and a successful mature enterprise
At present, lung cancer is usually detected at late stages, where survival rates are very low – about 15%. The reason for this is that lung cancer patients are mostly asymptomatic in early stages. Detecting lung cancer in early stages significantly improves survival rates to 50% to 80%, thus a good tool for lung cancer detection has huge potential.
The current high clinical results of Lung EpiCheck and the meetings with European potential customers (such as leading medical centers and lab chains) shows that the project proposed methodology and the expected performance is very promising to potential customers and market leaders. These potential customers have also confirmed company’s assumption about pricing that provides proper value for money. Nucleix’s technology is expected to create a huge value proposition to patients, physicians and payers identified as the main stakeholders
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
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Programme(s)
Funding Scheme
SME-2 - SME instrument phase 2Coordinator
7670203 REHOVOT
Israel
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.