Periodic Reporting for period 2 - denovoSkin (Personalized, bio-engineered skin grafts for the permanent treatment of skin defects)
Reporting period: 2019-10-01 to 2020-12-31
To address these problems Cutiss has developed denovoSkin™, the first hydrogel-based, autologous, permanent and safe bio-engineered, skin graft that is expected to minimize scar formation and ensure patient safety while lowering costs to national healthcare systems. denovoSkin™ is a patented, personalized, autologous bio-engineered human skin graft classified as Advanced Therapy Medical Product (ATMP). It is engineered to yield large quantities of skin graft surface starting-off from a stamp-sized skin biopsy of the patient, thus solving the donor site shortage issue. The work in Phase 2 of the SME instrument aims at enabling the production automation of denovoSkin™ to meet large-scale demand and maximise profitability while maintaining safety. Within the scope of the SME-I project, the main goal is to design, develop and integrate an automated and closed system for (skin) graft formation, with the ability of simultaneously fabricate enough skin grafts to treat at least 35% of the total body surface area of an adult patient (approx. 5000 cm^2).