Deconstructing the role of SUMO on chromatin in cell identity and tissue repair

Project Information

SUMiDENTITY

Grant agreement ID: 832294

DOI

10.3030/832294

Project closed

EC signature date 14 October 2019

Start date 1 January 2020

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 995,00

EU contribution

€ 2 499 995,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Extensive SUMO Modification of Repressive Chromatin Factors Distinguishes Pluripotent from Somatic Cells

Author(s): Ilan Theurillat, Ivo A. Hendriks, Jack-Christophe Cossec, Alexandra Andrieux, Michael L. Nielsen, Anne Dejean
Published in: Cell Reports, Issue 32/11, 2020, Page(s) 108146, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108146

Transient pharmacological inhibition of SUMOylation during pregnancy induces craniofacial malformations in offspring mice

Author(s): Jorge Mata-Garrido, Isabella Zafferri, Alice Nordlinger, Yann Loe-Mie, Anne Dejean, Jack-Christophe Cossec
Published in: European Journal of Cell Biology, Issue 104, 2026, Page(s) 151480, ISSN 0171-9335
Publisher: Elsevier BV
DOI: 10.1016/j.ejcb.2025.151480

Generation of embryo-like structures from mouse embryonic stem cells treated with a chemical inhibitor of SUMOylation and cultured in microdroplets

Author(s): Tatiana Traboulsi, Sébastien Sart, Charles N. Baroud, Anne Dejean, Jack-Christophe Cossec
Published in: STAR Protocols, Issue 4, 2025, Page(s) 102573, ISSN 2666-1667
Publisher: Elsevier BV
DOI: 10.1016/j.xpro.2023.102573

Z-DNA formation regulates the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization

Author(s): Shireen Shajahan, Yann Loe-Mie, Laure Asselin, Marion Salmon-Legagneur, Tatiana Traboulsi, Agnès Thierry, Anne Dejean, Jack-Christophe Cossec
Published in: Nature Structural & Molecular Biology, Issue 33, 2026, Page(s) 677-690, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-026-01751-5

SUMO operates from a unique long tandem repeat to keep innate immunity in check

Author(s): Amandine Goffeney, Ivo A Hendriks, Victoria Morel, Yann Loe-Mie, François Charon, Michael L Nielsen, Jack-Christophe Cossec, Daan Noordermeer, Jacob-Sebastian Seeler, Anne Dejean
Published in: Nucleic Acids Research, Issue 53, 2025, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaf750

An unanticipated tumor-suppressive role of the SUMO pathway in the intestine unveiled by Ubc9 haploinsufficiency

Author(s): Ignacio López, Eleftheria Chalatsi, Saskia I. J. Ellenbroek, Alexandra Andrieux, Pierre-François Roux, Juan P. Cerapio, Grégory Jouvion, Jacco van Rheenen, Jacob-S. Seeler, Anne Dejean
Published in: Oncogene, Issue 39/43, 2020, Page(s) 6692-6703, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-020-01457-y

Chemical inhibition of SUMOylation activates the FSHD locus

Author(s): Alice Nordlinger, Loéva Morin, Alexandra Andrieux, Jean Philippe Trani, Pierre Perrin, Nathalie Eudes, Anne Bigot, Anne Dejean, Frédérique Magdinier
Published in: Scientific Reports, Issue 16, 2026, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-025-33624-0

Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures

Author(s): Jack-Christophe Cossec, Tatiana Traboulsi, Sébastien Sart, Yann Loe-Mie, Manuel Guthmann, Ivo A Hendriks, Ilan Theurillat, Michael L Nielsen, Maria-Elena Torres-Padilla, Charles N Baroud, Anne Dejean
Published in: Cell Reports, 2023, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112380