Neuron-associated macrophages in the gut as novel target for the treatment of enteric neuropathies

Project Information

NEUMACS

Grant agreement ID: 833816

DOI 10.3030/833816

Project closed

EC signature date 10 May 2019

Start date 1 October 2019

End date 30 September 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

Publications

Peer reviewed articles (11)

Immune activation in irritable bowel syndrome: what is the evidence?

Author(s): Javier Aguilera-Lizarraga, Hind Hussein, Guy E. Boeckxstaens
Published in: Nature Reviews Immunology, Issue 22, 2023, Page(s) 674-686, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-022-00700-9

IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer

Author(s): Lies van Baarle, Veronica De Simone, Linda Schneider, Sneha Santhosh, Saeed Abdurahiman, Francesca Biscu, Reiner Schneider, Lisa Zanoletti, Renata Siqueira de Mello, Sara Verbandt, Zedong Hu, Michelle Stakenborg, Bo-Jun Ke, Nathalie Stakenborg, Raquel Salvador Laureano, Balbina García-Reyes, Jonas Henn, Marieta Toma, Maxime Vanmechelen, Guy Boeckxstaens, Frederik De Smet, Abhishek D. Garg, Sales
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-50438-2

Macrophages in the gut: masters in multitasking

Author(s): Delfini M, Stakenborg N, Viola MF, Boeckxstaens G
Published in: Immunity, Issue 10747613, 2022, Page(s) 1530-1548, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.08.005

How pain sensors make the gut weep

Author(s): Nathalie Stakenborg, Yaping Xue, Guy Boeckxstaens
Published in: Cell Research, Issue 33, 2023, Page(s) 339-340, ISSN 1001-0602
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-022-00768-x

Intestinal neuro-immune interactions: focus on macrophages, mast cells and innate lymphoid cells

Author(s): Nathalie Stakenborg, Maria F. Viola, Guy E. Boeckxstaens
Published in: Current Opinion in Neurobiology, Issue 62, 2020, Page(s) 68-75, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2019.11.020

The Efficacy of Peroral Endoscopic Myotomy vs Pneumatic Dilation as Treatment for Patients With Achalasia Suffering From Persistent or Recurrent Symptoms After Laparoscopic Heller Myotomy: A Randomized Clinical Trial

Author(s): Caroline M.G. Saleh, Pietro Familiari, Barbara A.J. Bastiaansen, Paul Fockens, Jan Tack, Guy Boeckxstaens, Raf Bisschops, Aaltje Lei, Marlies P. Schijven, Jan Guido Costamagna, Albert J. Bredenoord
Published in: Gastroenterology, Issue 164, 2024, Page(s) 1108-1118.e3, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2023.02.048

Niche-specific functional heterogeneity of intestinal resident macrophages

Author(s): Maria Francesca Viola, Guy Boeckxstaens
Published in: Gut, 2020, Page(s) gutjnl-2020-323121, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323121

Dedicated macrophages organize and maintain the enteric nervous system

Author(s): Maria Francesca Viola, Marta Chavero-Pieres, Elodie Modave, Marcello Delfini, Nathalie Stakenborg, Maria Cuende Estévez, Naomi Fabre, Iris Appeltans, Tobie Martens, Katy Vandereyken, Hannah Theobald, Jens Van Herck, Philippe Petry, Simon Verheijden, Sebastiaan De Schepper, Alejandro Sifrim, Zhaoyuan Liu, Florent Ginhoux, Mohamad Azhar, Andreas Schlitzer, Gianluca Matteoli, Katrin Kierdorf, Marco
Published in: Nature, Issue 618, 2023, Page(s) 818-826, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-06200-7

Magnetic resonance imaging as a non‐invasive tool to assess gastric emptying in mice

Author(s): Marta Chavero‐Pieres, Maria Francesca Viola, Iris Appeltans, Saeed Abdurahiman, Willy Gsell, Gianluca Matteoli, Uwe Himmelreich, Guy Boeckxstaens
Published in: Neurogastroenterology & Motility, Issue 35, 2023, ISSN 1350-1925
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/nmo.14490

Intestinal resident macrophages: Multitaskers of the gut

Author(s): Maria Francesca Viola, Guy Boeckxstaens
Published in: Neurogastroenterology & Motility, Issue 32/8, 2020, ISSN 1350-1925
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/nmo.13843

Immune-mediated food reactions in irritable bowel syndrome

Author(s): Hind Hussein, Guy E. Boeckxstaens
Published in: Current Opinion in Pharmacology, Issue 66, 2024, Page(s) 102285, ISSN 1471-4892
Publisher: Elsevier BV
DOI: 10.1016/j.coph.2022.102285

Non-peer reviewed articles (2)

Muscularis macrophages: trained guardians of enteric neurons

Author(s): Viola MF, Boeckxstaens G
Published in: Cell Res, 2022, ISSN 1001-0602
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-021-00602-w

Shining light on the neuro-immune axis in the gut

Author(s): Nathalie Stakenborg, Guy E. Boeckxstaens
Published in: Immunity, Issue 54/5, 2021, Page(s) 850-852, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.04.016