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Synthetic photobiology for light controllable active matter

Project description

Light moves synthetic bacteria and could control the speed of future miniature cargo trucks

Nature is perhaps the greatest engineer of all time. Scientists strive to mimic natural phenomena and benefit from their inherent efficiency and simplicity. Self-propelled colloids, a type of synthetic active matter similar to self-propelled bacteria, are among the many accomplishments. In addition to the synthetic machinery for motion, scientists have also identified the genetic components required to impart responsiveness to the environment. SYGMA is using the genetic building blocks of functional properties to create light-controllable active matter. Engineered photoreceptors sensitive to red, green, and blue much like cones in the retina will be linked to cellular processes that modulate things like speed, growth, and death. Light control of fleets of mini cargo transporters could be around the corner.

Objective

From a Physics and Engineering standpoint, swimming bacteria are a formidable example of self-propelled micro-machines. Together with their synthetic counterpart, self-propelled colloids, they represent the “living” atoms of active matter, an exciting branch of contemporary soft matter and statistical mechanics. Differently from synthetic colloids, however, each bacterial cell contains all the molecular machinery that is required to self-replicate, sense the environment, process information and compute responses. Breaking down these biological functions into basic genetic parts has been one of the greatest triumphs of molecular biology. Today, synthetic biologists are assembling these parts into new genetic programs and exploiting bacteria as computing micro-machines.
Project SYGMA will employ the synthetic biology toolkit to provide the building blocks for a light controllable active matter having reliable, reconfigurable and interactively tunable dynamical properties. We will first engineer transmembrane photoreceptors to wire RGB external light signals to cellular physical responses like speed, tumbling, growth and death rates. These genetic parts will allow the modular design of customized active particles to build active materials with unprecedented optical control capabilities. Using these new tools we will address, with experiments and theory, fundamental questions like: how fast can we drive particle density using spatio-temporal motility modulations? what is the force on a body suspended in a bath of bacteria with non uniform motility? how do physical forces contribute to morphogenesis in bacterial colonies? Finding quantitative and experimentally validated answers will eventually allow us to engineer structured illumination protocols to mold living microstructures, transport colloidal cargos by shaping active pressure, control swarms of biohybrid microcars and shape bacterial microcolonies.

Keywords

Host institution

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Net EU contribution
€ 1 018 750,00
Address
Piazzale Aldo Moro 5
00185 Roma
Italy

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Region
Centro (IT) Lazio Roma
Activity type
Higher or Secondary Education Establishments
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Total cost
€ 1 018 750,00

Beneficiaries (3)