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Visualising age- and cataract-related changed within cell membranes of human eye lens using molecular rotors

Project description

Insight into the cataract-associated structural changes of the lens

Intriguingly, there is no turnover in lipids and proteins in the lens of the mammalian eye. As a result, defects in these molecules during ageing alter membrane structure and impair metabolite transport, causing cataract, a condition associated with clouding of the lens. The EU-funded Cata-rotors project will use fluorescence lifetime imaging microscopy to determine age-related changes in the structure of lens cell membranes and how they lead to cataract development. Oxidation-induced damage in an animal model will also shed light on the general mechanism of lens ageing, paving the way for novel treatments for cataract.

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Net EU contribution
€ 224 933,76
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00