Visualising age- and cataract-related changed within cell membranes of human eye lens using molecular rotors

Project description

Insight into the cataract-associated structural changes of the lens

Intriguingly, there is no turnover in lipids and proteins in the lens of the mammalian eye. As a result, defects in these molecules during ageing alter membrane structure and impair metabolite transport, causing cataract, a condition associated with clouding of the lens. The EU-funded Cata-rotors project will use fluorescence lifetime imaging microscopy to determine age-related changes in the structure of lens cell membranes and how they lead to cataract development. Oxidation-induced damage in an animal model will also shed light on the general mechanism of lens ageing, paving the way for novel treatments for cataract.

Fields of science

• natural sciences › chemical sciences › electrochemistry › electrolysis
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › physical sciences › optics › microscopy › fluorescence lifetime imaging
• natural sciences › biological sciences › biochemistry › biomolecules › lipids
• natural sciences › biological sciences › biophysics

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

Net EU contribution

€ 224 933,76

Address

South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom

Region

London › Inner London — West › Westminster

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00