Innovative 3D preclinical cancer model of brain metastases
The EU-funded 3DBrainStrom project aims to establish 3D-printed models of brain metastases that include brain extracellular matrix, stroma and serum containing immune cells flowing in functional vessels. The models will better capture clinical tissue properties, signalling pathways, haemodynamics and drug responsiveness. The researchers will exploit the new models to design three therapeutic approaches to target cellular compartments involved in brain metastases: the prevention of brain metastatic colonisation using targeted nanovaccines; the inhibition of tumour–brain stroma cells crosstalk during micrometastases progression; and the selective targeting of tumour cells. The new preclinical cancer models will bridge the translational gap in cancer therapeutics.
Fields of science
Funding SchemeERC-ADG - Advanced Grant
69978 Tel Aviv
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