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Brain metastases: Deciphering tumor-stroma interactions in three dimensions for the rational design of nanomedicines

Project description

Innovative 3D preclinical cancer model of brain metastases

The EU-funded 3DBrainStrom project aims to establish 3D-printed models of brain metastases that include brain extracellular matrix, stroma and serum containing immune cells flowing in functional vessels. The models will better capture clinical tissue properties, signalling pathways, haemodynamics and drug responsiveness. The researchers will exploit the new models to design three therapeutic approaches to target cellular compartments involved in brain metastases: the prevention of brain metastatic colonisation using targeted nanovaccines; the inhibition of tumour–brain stroma cells crosstalk during micrometastases progression; and the selective targeting of tumour cells. The new preclinical cancer models will bridge the translational gap in cancer therapeutics.

Host institution

TEL AVIV UNIVERSITY
Net EU contribution
€ 2 353 125,00
Address
Ramat Aviv
69978 Tel Aviv
Israel

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (1)

TEL AVIV UNIVERSITY
Israel
Net EU contribution
€ 2 353 125,00
Other funding
€ 0,00