Skip to main content

Functional analysis of URI, a novel component of the TOR signalling pathway involved in nutrient metabolism regulation


The mammalian phosphoinositide (PI) 3-kinase-related kinase mTOR (mammalian target of rapamycin) occupies a central role in a signalling pathway involved in the control of cell growth and proliferation. It integrates signals arising from nutritional cues as well as hormones/growth factors to regulate growth by altering translation and transcription programs.

Not surprisingly, alterations in this pathway has been directly linked to a number of disease states including cancer. The host laboratory has recently discovered a novel evolutionary conserved protein, termed URI, that operates downstream of TOR in both yeast and mammalian cells to contribute, directly or indirectly, to rapamycin-sensitive gene expression.

In this proposal, we aim at
- elucidating the function(s) of URI in cell growth and proliferation in mammalian cells,
- determining the significance of rapamycin-sensitive phosphorylation of URI in modulating its function in growth control and gene expression and
- identifying novel interaction partners of URI. The proposed studies will provide new leads towards a clearer understanding of URI function(s) in cell growth and proliferation and the mechanism underlying the control of cell growth and gene expression by mTOR.

Call for proposal

See other projects for this call

Funding Scheme

EIF - Marie Curie actions-Intra-European Fellowships


Rã¤mistrasse 101