Objective
The direct catalytic functionalization of C-H bonds, an ubiquitous motif in organic molecules, represents a paradigm shift in the standard logic of organic synthesis. One of the major challenges to render this approach synthetically useful is to control the site-selectivity because most organic molecules exhibit several similar aliphatic C-H bonds.
The functionalization of aliphatic C-H bond mediated by photoredox catalysis is a highly active field of research. To date, state-of-the-art site-selective methods in this field rely on substrate control which are inherently restricted to the functionalization of a single C-H bond within the substrate backbone. The innovative aspect of this research program is to target catalyst control to allow the site-selective functionalization of several different C-H bonds of a single substrate. Through this approach, we wish to go beyond the challenging problem of site-selectivity to enable site-divergent functionalizations. Such a breakthrough would provide a new tool for a flexible and streamlined access to molecular complexity from chemical feedstocks.
To achieve our objectives, we plan to develop novel bifunctional catalysts incorporating one moiety able to engage into dynamic non-covalent interactions with the substrate and another functional group able to perform Hydrogen Atom Transfer (HAT) processes. These two functional groups are connected by an inert spacer which will position the HAT unit in proximity to a particular C-H bond of the substrate, thus controlling site-selectivity for the C-H activation event. By varying the nature of the spacer, we expect to selectively functionalize several different positions of linear alkyl chains possessing almost undistinguishable methylene C-H bonds.
Overall, BICACH aims at using simple bifunctional organocatalysts and light energy to trigger highly challenging C-H functionalization processes. In addition, it offers a unique training to the ER with broad future research perspectives.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
93053 Regensburg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.