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Circuit mechanisms for behavioral choice from complete CNS activity and connectivity maps

Project description

Studying neuronal mechanisms of behavioural choice

Behavioural choice plays a crucial role in an animal’s survival. However, the related fundamental neuronal mechanisms are not well understood because the circuits involve several brain regions. While the connectome structurally connects all potential circuits, it is insufficient to drive functional models. Recent developments in microscopy allow neuronal activity monitoring across entire brains. The EU-funded BICE project proposes a method to observe and identify neurons with significant activity standards by which the same sample goes through whole-brain functional imaging and subsequent electron microscopy imaging. To identify circuit mechanisms that promote one action while repressing others, the project will study the neuronal mechanisms of behavioural choice in Drosophila melanogaster larvae.

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Net EU contribution
€ 212 933,76
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00