Objective
Pyroptosis is a highly inflammatory form of cell death that drives host protection against intracellular pathogens. Pyroptosis is initiated by inflammasome-activated inflammatory caspases (e.g. caspase-1/4/5/11), which cleave gasdermin D to trigger plasma membrane pores. In contrast, apoptosis is driven by apoptotic caspases (e.g. caspase-3/7/8/9), and is traditionally classified as an immunologically silent form of cell death that is important for development and maintenance of homeostasis. However, emerging studies suggest that caspase-8 activation during extrinsic apoptosis promotes inflammation by triggering the assembly of a proinflammatory, multi-protein complex called the NLRP3 inflammasome, through an ill-defined mechanism. A recent study identified a caspase-3 cleavage site within gasdermin D; cleavage of gasdermin D by apoptotic caspase-3 suppresses the cytotoxic function of this protein. These suggest a complex crosstalk between the pyroptosis and apoptosis. Therefore, the aim of this project is to investigate 1) novel proinflammatory functions of gasdermin D during extrinsic apoptosis; 2) the role of gasdermin D in caspase-8-dependent NLRP3 activation; and 3) the importance of caspase-3-mediated gasdermin D inactivation at steady state in vivo and during chemotherapy. This project will greatly enhance the skills and competence of the experienced researcher through advanced training and international mobility, and is in line with Horizon 2020 Work Programme objective.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1015 LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.