Functional dissection of X-linked regulatory DNA: unravelling the impact of genome topology on transcriptional regulation

Project description

The interconnection between chromosomal topology and transcriptional regulation

Accumulating evidence indicates that mammalian genomes are organised in topologically distinct subdomains which interact with each other and share regulatory landscape. Although disruption of these domains has been associated with disease, little is known whether they are a consequence of transcriptional activity. Scientists of the EU-funded eXcape3D project will use the X chromosome inactivation (XCI) as a model system to identify the regulatory elements implicated in the formation of chromosomal subdomains. The project will provide important insight into genome topology and the role of the non-coding genome in gene regulation.

Fields of science

• social sciences › educational sciences
• natural sciences › biological sciences › genetics › DNA
• natural sciences › mathematics › pure mathematics › topology
• natural sciences › biological sciences › genetics › chromosomes
• natural sciences › biological sciences › genetics › genomes

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Net EU contribution

€ 174 806,40

Address

Meyerhofstrasse 1
69117 Heidelberg
Germany

Region

Baden-Württemberg › Karlsruhe › Heidelberg, Stadtkreis

Activity type

Research Organisations

Links

Other funding

€ 174 806,40