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Functional dissection of X-linked regulatory DNA: unravelling the impact of genome topology on transcriptional regulation

Project description

The interconnection between chromosomal topology and transcriptional regulation

Accumulating evidence indicates that mammalian genomes are organised in topologically distinct subdomains which interact with each other and share regulatory landscape. Although disruption of these domains has been associated with disease, little is known whether they are a consequence of transcriptional activity. Scientists of the EU-funded eXcape3D project will use the X chromosome inactivation (XCI) as a model system to identify the regulatory elements implicated in the formation of chromosomal subdomains. The project will provide important insight into genome topology and the role of the non-coding genome in gene regulation.

Coordinator

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Net EU contribution
€ 174 806,40
Address
Meyerhofstrasse 1
69117 Heidelberg
Germany

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Research Organisations
Other funding
€ 174 806,40