Project description
Block copolymers phase-separation for environment-friendly chemicals
A cell can control a specific metabolic pathway by spatial separation of functional macromolecules. What if this were transferred to artificial materials? This would make it possible to study the influence of spatial effects on biochemical pathways and the development of new technologies for non-cellular applications like the eco-friendly preparation of valuable chemicals or synthetic intermediates. The EU-funded enzymeCOMP project will exploit the power of controlled block copolymers phase-separation in the confinement of nanoparticles. Nanoparticles can provide structural support and spatial proximity increasing product formation. This makes nanostructured particles ideal candidates for providing unique domains for enzyme compartmentalisation by external post-assembly functionalisation.
Objective
"Nature has the unique ability to program macroscopic functions via the morphology of nano-scopic systems. One way the cell can control a certain metabolic pathway is by spatial separation of functional macromolecules. Transferring this high level of control to artificial materials would allow not only to study the influence of spatial effects on biochemical pathways, but also to develop new technologies for non-cellular applications. These include the environment-friendly and high-yielding preparation of valuable chemicals or synthetic intermediates. To address this task, the proposed project will exploit the power of controlled block copolymers phase-separation in the confinement of nanoparticles. Nanoparticles can provide structural support and spatial proximity that could ultimately increase product formation. In this context, nanostructured particles are ideal candidates providing unique domains for enzyme compartmentalization by external post-assembly functionalization. In this research project we propose to use poly(styrene)-block-poly(butadiene) nanoparticles as a matrix for post-assembly and domain-selective anchoring of enzymes. For this, two new functionalized polymeric surfactants will be obtained: poly(styrene)-block-poly(ethylene glycol)-""X"" and poly(butadiene)-block-poly(ethylene glycol)-""Y"". Where ""X"" and ""Y"" represent orthogonal reactive groups, which should allow selective attachment of any two enzymes. We proposed the synthesis of striped ellipsoidal nanoparticles where each domain will contain one type of enzyme of a cascade system. We aim for this tandem configuration of one enzyme next to the other to increase the rate of the overall enzymatic reaction. The success of this project could ultimately change the paradigm of the conventional chemistry industry to an environment-friendly approach."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology nanotechnology nano-materials
- natural sciences chemical sciences organic chemistry aliphatic compounds
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
14195 BERLIN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.